Huang K, Peyman G A, McGetrick J
Ophthalmic Surg. 1979 Mar;10(3):84-6.
In studying the dose-related ocular toxicity of amphotericin B in vitrectomized eyes, up to 5 micrograms/0.1 ml concentration of amphotericin C was nontoxic to the ocular structure when injected in the anterior part of the vitreous cavity. Intravitreal injection of 2.5 micrograms of amphotericin B halted fungal endophthalmitis, which was experimentally induced in rabbit eyes, even after 16 days of infection. Combined treatment of vitrectomy and intravitreal injection of amphotericin B not only cured the fungal endophthalmitis but it also cleared the ocular media from opacities.
在研究两性霉素B对玻璃体切除术后眼睛的剂量相关眼毒性时，当在玻璃体腔前部注射浓度高达5微克/0.1毫升的两性霉素C时，对眼结构无毒。玻璃体内注射2.5微克两性霉素B可阻止在兔眼实验性诱导的真菌性眼内炎，即使在感染16天后也是如此。玻璃体切除术和玻璃体内注射两性霉素B的联合治疗不仅治愈了真菌性眼内炎，还清除了眼内介质的混浊。
