Feng F, Zhou B, Wang L, Yao H X, Guo Y E, An N Y, Wang L N, Zhang X
Department of Neurology, the Second Medical Center, Chinese PLA General Hospital, Beijing 100853, China; National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China; Department of Neurology, PLA Rocket Force Characteristic Medical Center, Beijing 100088, China.
Department of Neurology, the Second Medical Center, Chinese PLA General Hospital, Beijing 100853, China; National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China.
Zhonghua Nei Ke Za Zhi. 2019 Sep 1;58(9):662-667. doi: 10.3760/cma.j.issn.0578-1426.2019.09.006.
To investigate the correlation of functional connectivity (FC) and the integrity of connective fibres between hippocampus and thalamus in Alzheimer's disease(AD) and amnestic mild cognitive impairment (aMCI). Both resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion tensor imaging (DTI) data of 40 AD patients, 37 aMCI patients and 41 normal control subjects matching with age and educational level were collected. These subjects were all recruited from outpatient Department of Neurology in the Second Medical Center of Chinese PLA General Hospital, as well as poster, from May 2016 to January 2018. The FC strength between bilateral hippocampus and thalamus, as well as the parameters representing integrity of connective fibres, including fractional anisotropy (FA) and mean diffusivity(MD),were analyzed. Also, the correlations between FC strength and FA or MD strength were analyzed in the study. Compared to that of normal control subjects, the FC strength between billateral hippocampus and thalamus in patients with AD, aMCI were not significantly different(>0.05). The integrity of bilateral connective fibres between hippocampus and thalamus were damaged in AD patients when compared to normal control subjects(<0.01). A positive correlation of connective fibres integrity with FC strength between hippocampus and thalamus was found in the left side(=0.25,<0.05) but rather in the right side. In AD and aMCI patients, structural connectivity between left hippocampus and thalamus affects the functional connectivity between them.
探讨阿尔茨海默病（AD）和遗忘型轻度认知障碍（aMCI）患者海马体与丘脑之间的功能连接（FC）与结缔纤维完整性的相关性。收集了40例AD患者、37例aMCI患者以及41名年龄和教育水平相匹配的正常对照者的静息态功能磁共振成像（rs-fMRI）和扩散张量成像（DTI）数据。这些受试者均于2016年5月至2018年1月从中国人民解放军总医院第二医学中心神经内科门诊招募，以及通过海报招募。分析双侧海马体与丘脑之间的FC强度，以及代表结缔纤维完整性的参数，包括分数各向异性（FA）和平均扩散率（MD）。此外，本研究还分析了FC强度与FA或MD强度之间的相关性。与正常对照者相比，AD患者和aMCI患者双侧海马体与丘脑之间的FC强度无显著差异（>0.05）。与正常对照者相比，AD患者海马体与丘脑之间双侧结缔纤维的完整性受损（<0.01）。在左侧发现结缔纤维完整性与海马体和丘脑之间的FC强度呈正相关（=0.25，<0.05），但右侧并非如此。在AD和aMCI患者中，左侧海马体与丘脑之间的结构连接影响它们之间的功能连接。
