Faculty of Basic and Biomedical Sciences, Paris Descartes University, INSERM UMRS 1124, 75006 Paris, France.
Int J Mol Sci. 2019 Aug 27;20(17):4192. doi: 10.3390/ijms20174192.
Recent research in the last decade has sought to explore the role and therapeutic potential of Liver X Receptors (LXRs) in the physiology and pathologies of the Peripheral Nervous System. LXRs have been shown to be important in maintaining the redox homeostasis in peripheral nerves for proper myelination, and they regulate ER stress in sensory neurons. Furthermore, LXR stimulation has a positive impact on abrogating the effects of diabetic peripheral neuropathy and obesity-induced allodynia in the Peripheral Nervous System (PNS). This review details these findings and addresses certain important questions that are yet to be answered. The potential roles of LXRs in different cells of the PNS are speculated based on existing knowledge. The review also aims to provide important perspectives for further research in elucidating the role of LXRs and assessing the potential of LXR based therapies to combat pathologies of the Peripheral Nervous System.
近十年来的研究旨在探讨肝 X 受体 (LXRs) 在周围神经系统的生理和病理中的作用和治疗潜力。研究表明，LXRs 对于维持外周神经中的氧化还原稳态以实现适当的髓鞘形成非常重要，并且它们调节感觉神经元中的内质网应激。此外，LXR 刺激对消除糖尿病周围神经病变和肥胖引起的周围神经系统 (PNS) 感觉过敏有积极影响。本综述详细介绍了这些发现，并讨论了一些尚未解决的重要问题。基于现有知识，推测了 LXR 在 PNS 不同细胞中的潜在作用。该综述还旨在为进一步研究提供重要视角，以阐明 LXR 的作用，并评估基于 LXR 的治疗方法对抗周围神经系统疾病的潜力。
