学龄儿童慢性咳嗽的相关病因及其临床特征
Etiologies associated with chronic cough and its clinical characteristics in school-age children.
作者信息
Yu Xingmei, Kong Lingjun, Jiang Wujun, Dai Yinfang, Wang Yuqing, Huang Li, Luo Wei, Lai Kefang, Hao Chuangli
机构信息
Department of Respiratory Medicine, Children's Hospital of Soochow University, Suzhou 215003, China.
Department of Hematology, Children's Hospital of Soochow University, Suzhou 215003, China.
出版信息
J Thorac Dis. 2019 Jul;11(7):3093-3102. doi: 10.21037/jtd.2019.07.36.
BACKGROUND
To comprehensively evaluate the etiology of chronic cough and the value of clinical feature in school age children in Suzhou, China.
METHODS
School-age (6-14 years) children newly referred with chronic cough (>4 weeks) were prospectively evaluated by utilizing a diagnostic algorithm in this study. Clinical features of different etiologies of chronic cough were also investigated.
RESULTS
In total, 118 patients were enrolled in the study. The cough duration ranged from 1 to 76 months. Upper airway cough syndrome (UACS) was found in 77 (65.3%) patients with chronic cough, cough-variant asthma (CVA) in 57 (48.3%) patients, protracted bronchitis (PB) in 15 (12.7%) patients, gastroesophageal reflux disease (GERD) in 7 (5.9%) patients, tic disorders (TD) in 3 (2.5%) patients and eosinophilic bronchitis (EB) in 2 (1.7%) patients. A single etiology was present in 75 patients and multiple etiologies were present in 43 patients. The three most common single etiologies were UACS (31.4%), CVA (14.4%), and PB (10.2%), followed by GERD (5.9%), and EB (1.7%). The most common multiple etiology was CVA + UACS (31.4%), followed by CVA + PB (2.5%), and TD + UACS (2.5%).
CONCLUSIONS
The common etiologies of chronic cough in school-age children were UACS, CVA, and PB, while EB and GERD were rare.
背景
全面评估中国苏州学龄儿童慢性咳嗽的病因及临床特征的价值。
方法
本研究采用诊断算法对新转诊的学龄期（6 - 14岁）慢性咳嗽（>4周）儿童进行前瞻性评估。还调查了慢性咳嗽不同病因的临床特征。
结果
本研究共纳入118例患者。咳嗽持续时间为1至76个月。77例（65.3%）慢性咳嗽患者被诊断为上气道咳嗽综合征（UACS），57例（48.3%）为咳嗽变异性哮喘（CVA），15例（12.7%）为迁延性支气管炎（PB），7例（5.9%）为胃食管反流病（GERD），3例（2.5%）为抽动障碍（TD），2例（1.7%）为嗜酸性粒细胞性支气管炎（EB）。75例患者为单一病因，43例患者为多种病因。三种最常见的单一病因是UACS（31.4%）、CVA（14.4%）和PB（10.2%），其次是GERD（5.9%）和EB（1.7%）。最常见的多种病因是CVA + UACS（31.4%），其次是CVA + PB（2.5%）和TD + UACS（2.5%）。
结论
学龄儿童慢性咳嗽的常见病因是UACS、CVA和PB，而EB和GERD较为罕见。
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