一项针对中国慢性咳嗽病因的前瞻性、多中心调查。

A prospective, multicenter survey on causes of chronic cough in China.

机构信息

State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong.

China-Japan Friendship Hospital, Beijing.

出版信息

Chest. 2013 Mar;143(3):613-620. doi: 10.1378/chest.12-0441.

DOI:10.1378/chest.12-0441

PMID:23238526

Abstract

BACKGROUND

The causes of chronic cough in China and its relations with geography, seasonality, age, and sex are largely uncertain.

METHODS

A prospective, multicenter survey was conducted to evaluate patients with chronic cough across five regions in China by using a modified diagnostic algorithm. The effects of geography, seasonality, age, and sex on spectrum of chronic cough were also investigated.

RESULTS

The current study evaluated 704 adult patients, including 315 men (44.7%) and 389 women (55.3%). The causes of chronic cough were determined in 640 subjects (90.9%). Common causes included cough variant asthma (CVA) (32.6%), upper airway cough syndrome (UACS) (18.6%), eosinophilic bronchitis (EB) (17.2%), and atopic cough (AC) (13.2%). Collectively, these four causes accounted for 75.2% to 87.6% across five different regions without significant difference (P > .05), although there was variation on single causes. Gastroesophageal reflux-related cough was identified in 4.6% of causes. Seasonality, sex, and age were not associated with the spectrum of chronic cough (all P > .05).

CONCLUSION

CVA, UACS, EB, and AC were common causes of chronic cough in China. Geography, seasonality, age, and sex were not associated with the spectrum of chronic cough.

摘要

背景

中国慢性咳嗽的病因及其与地理、季节、年龄和性别之间的关系在很大程度上尚不清楚。

方法

采用改良诊断算法，对中国五个地区的慢性咳嗽患者进行前瞻性、多中心调查，评估患者情况。同时还研究了地理、季节、年龄和性别对慢性咳嗽谱的影响。

结果

本研究共评估了 704 例成年患者，其中男性 315 例（44.7%），女性 389 例（55.3%）。640 例患者（90.9%）确定了慢性咳嗽的病因。常见病因包括咳嗽变异性哮喘（CVA）（32.6%）、上气道咳嗽综合征（UACS）（18.6%）、嗜酸粒细胞性支气管炎（EB）（17.2%）和变应性咳嗽（AC）（13.2%）。这四种病因在五个不同地区的总占比为 75.2%~87.6%，差异无统计学意义（P >.05），尽管各病因的占比存在差异。胃食管反流相关咳嗽占病因的 4.6%。季节、性别和年龄与慢性咳嗽谱无关（均 P >.05）。