1999 - 2004年美国国家健康与营养检查调查中的焦虑、C反应蛋白与肥胖
Anxiety, C-reactive protein, and obesity in NHANES 1999-2004.
作者信息
Persons Jane E, Pierce Gary L, Fiedorowicz Jess G
机构信息
Carver College of Medicine, United States.
Department of Health and Human Physiology, College of Liberal Arts and Sciences, United States.
出版信息
Heliyon. 2019 Aug 17;5(8):e02267. doi: 10.1016/j.heliyon.2019.e02267. eCollection 2019 Aug.
Abstract
The inflammatory marker C-reactive protein has been linked to anxiety across a number of studies. This paper uses data for 1,439 participants of the National Health and Nutrition Examination Survey (NHANES) 1999-2004 to examine the association between anxiety and C-reactive protein (CRP), and the potential for moderation by body mass index. No association was found between anxiety or depression and CRP in unadjusted or multivariable-adjusted logistic regression analyses, nor was there evidence of moderation by continuous BMI, BMI class, or obesity. Future studies on the relationship between anxiety and CRP should utilize larger general population samples or populations with a high prevalence of anxiety. There is also a need for prospective studies in this area to better discern the temporal relationships between anxiety and inflammation.
摘要
多项研究表明，炎症标志物C反应蛋白与焦虑有关。本文利用1999 - 2004年美国国家健康与营养检查调查（NHANES）中1439名参与者的数据，研究焦虑与C反应蛋白（CRP）之间的关联，以及体重指数的调节作用。在未调整或多变量调整的逻辑回归分析中，未发现焦虑或抑郁与CRP之间存在关联，也没有证据表明连续BMI、BMI类别或肥胖具有调节作用。未来关于焦虑与CRP关系的研究应使用更大的普通人群样本或焦虑患病率高的人群。该领域也需要进行前瞻性研究，以更好地辨别焦虑与炎症之间的时间关系。
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