Department of Surgical Oncology The University of Tokyo 7-3-1 Hongo, Bunkyo-ku Tokyo, 113-8655 Japan.
BJS Open. 2019 Mar 13;3(4):436-444. doi: 10.1002/bjs5.50149. eCollection 2019 Aug.
The presence of extraintestinal manifestations may be associated with the development of pouchitis in patients with ulcerative colitis after ileal pouch-anal anastomosis. The aim of this study was to assess this correlation.
A systematic literature search was performed using MEDLINE and the Cochrane Library. Studies published in English up to 22 May 2017 investigating the association between extraintestinal manifestations and development of pouchitis in adults with ulcerative colitis were included. Case reports were excluded. The association of extraintestinal manifestations with the development of overall and chronic pouchitis was investigated using a random-effects model.
Of 1010 citations identified, 22 observational studies comprising 5128 patients were selected for analysis. The presence of extraintestinal manifestations was significantly associated with both chronic pouchitis (odds ratio 2·28, 95 per cent c.i. 1·57 to 3·32; = 0·001) and overall pouchitis (odds ratio 1·96, 1·49 to 2·57; < 0·001).
The presence of extraintestinal manifestations is associated with development of pouchitis after ileal pouch-anal anastomosis.
在回肠储袋-肛管吻合术后，溃疡性结肠炎患者出现肠外表现可能与储袋炎的发生有关。本研究旨在评估这种相关性。
使用 MEDLINE 和 Cochrane 图书馆进行系统文献检索。纳入了截至 2017 年 5 月 22 日发表的、研究溃疡性结肠炎成人患者肠外表现与储袋炎发展之间关系的英文研究。排除病例报告。使用随机效应模型研究肠外表现与总体和慢性储袋炎发展的相关性。
在确定的 1010 条引文当中，有 22 项观察性研究共纳入 5128 例患者，对这些研究进行了分析。肠外表现的存在与慢性储袋炎（优势比 2.28，95%置信区间 1.57 至 3.32； = 0.001）和总体储袋炎（优势比 1.96，1.49 至 2.57； < 0.001）均显著相关。
肠外表现的存在与回肠储袋-肛管吻合术后储袋炎的发生有关。
