Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Phytother Res. 2019 Dec;33(12):3040-3053. doi: 10.1002/ptr.6492. Epub 2019 Aug 29.
The metabolic syndrome (MetS) is a cluster of multiple conditions that includes hypertension, dyslipidemia, abdominal obesity, and hyperglycemia disorders. Most studies revealed that the MetS is accompanied with an increased risk for cardiovascular disease, Type 2 diabetes mellitus, and insulin resistance. It can be said that, in treating or preventing the MetS and its components, lifestyle adjustment and weight loss have a vital role. According to various studies, among natural compounds, celery (Apium graveolens) is one of the most important sources of phytochemicals such as phenolic acids, flavones, flavonols, and antioxidants such as vitamin C, beta-carotene (Provitamin A), and manganese. These antioxidants have a role in decreasing the oxidative damage. The phytochemicals in celery decrease the activity of proinflammatory cytokines and prevent inflammation. Also, flavonoids in celery suppress cardiovascular inflammation. Oxidative stress and inflammation in the blood stream are the main risk factors in increasing cardiovascular disease, especially atherosclerosis. Celery phthalides leads to expanding of smooth muscle in the blood vessels and lower blood pressure. As a result, the most active ingredients in celery (A. graveolens (have shown hypolipidemic, antidiabetic, and hypotensive properties. In this review, we summarized the mechanisms underlying the protective effects of celery components on insulin action, glucose, lipid metabolism, and blood pressure.
代谢综合征（MetS）是一组多种病症的集合，包括高血压、血脂异常、腹部肥胖和高血糖紊乱。大多数研究表明，MetS 伴随着心血管疾病、2 型糖尿病和胰岛素抵抗风险的增加。可以说，在治疗或预防 MetS 及其成分方面，生活方式的调整和减肥起着至关重要的作用。根据各种研究，在天然化合物中，芹菜（Apium graveolens）是植物化学物质（如酚酸、黄酮、黄酮醇和抗氧化剂如维生素 C、β-胡萝卜素（维生素 A 前体）和锰）的最重要来源之一。这些抗氧化剂在减少氧化损伤方面发挥作用。芹菜中的植物化学物质可降低促炎细胞因子的活性并预防炎症。此外，芹菜中的类黄酮可抑制心血管炎症。血流中的氧化应激和炎症是增加心血管疾病（尤其是动脉粥样硬化）的主要风险因素。芹菜苯酞可导致血管平滑肌扩张和降低血压。因此，芹菜（A. graveolens）中最活跃的成分（具有降血脂、抗糖尿病和降血压的特性。在这篇综述中，我们总结了芹菜成分对胰岛素作用、葡萄糖、脂质代谢和血压的保护作用的潜在机制。
