Rodriguez Velazquez Desiderio, Forte Lucrezia, Varela Guerrero Jorge Antonio, Díaz Alvarado Tonantzin, Elghandour Mona M M Y, Maggiolino Aristide, De Palo Pasquale, Salem Abdelfattah Z M
Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca C.P. 50000, Estado de México, Mexico.
Department of Veterinary Medicine, University of Bari, 70010 Valenzano, Italy.
Animals (Basel). 2025 Apr 28;15(9):1245. doi: 10.3390/ani15091245.
Exploring new natural-origin antiparasitic alternatives is essential in addressing the resistance issues that have emerged due to the widespread use of chemical or synthetic antiparasitic compounds. This area remains relatively underexplored despite the increasing recognition of plants like (mesquite) for their antiparasitic properties and nutritional value as a high-protein animal feed. This review aims to investigate the antiparasitic potential of against gastrointestinal parasites in horses. The review incorporates sources from 2005 to 2024. It was found that various phytochemical compounds from , particularly alkaloids, have demonstrated significant antiparasitic activity. Alkaloids are the most studied group due to their antibacterial, antiparasitic, and cytotoxic properties. According to the literature, the phytochemicals produced by hold promise as a potential solution for combating gastrointestinal parasites in horses. However, while preliminary findings suggest promising results, in vivo studies are necessary to evaluate the precise antiparasitic efficacy of these compounds and to determine the appropriate IC50 doses of alkaloids in horses, as well as to assess potential toxicity and side effects associated with their use.
探索新的天然来源抗寄生虫替代品对于解决因广泛使用化学或合成抗寄生虫化合物而出现的耐药性问题至关重要。尽管人们越来越认识到诸如牧豆树等植物具有抗寄生虫特性以及作为高蛋白动物饲料的营养价值，但该领域仍相对未得到充分探索。本综述旨在研究牧豆树对马胃肠道寄生虫的抗寄生虫潜力。该综述纳入了2005年至2024年的资料来源。研究发现，牧豆树中的各种植物化学化合物，特别是生物碱，已显示出显著的抗寄生虫活性。由于生物碱具有抗菌、抗寄生虫和细胞毒性特性，因此是研究最多的一类。根据文献，牧豆树产生的植物化学物质有望成为对抗马胃肠道寄生虫的潜在解决方案。然而，虽然初步研究结果显示出有希望的结果，但仍需要进行体内研究，以评估这些化合物的确切抗寄生虫功效，确定马体内牧豆树生物碱的合适半数抑制浓度（IC50）剂量，以及评估与使用它们相关的潜在毒性和副作用。
