School of Mechatronics Engineering, Harbin Institute of Technology, Harbin, 150001, China.
State Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin, 150001, China.
Small. 2019 Oct;15(42):e1903098. doi: 10.1002/smll.201903098. Epub 2019 Aug 29.
The separate co-encapsulation and selective controlled release of multiple encapsulants in a predetermined sequence has potentially important applications for drug delivery and tissue engineering. However, the selective controlled release of distinct contents upon one triggering event for most existing microcarriers still remains challenging. Here, novel microfluidic fabrication of compound-droplet-pairs-filled hydrogel microfibers (C-Fibers) is presented for two-step selective controlled release under AC electric field. The parallel arranged compound droplets enable the separate co-encapsulation of distinct contents in a single microfiber, and the release sequence is guaranteed by the discrepancy of the shell thickness or core conductivity of the encapsulated droplets. This is demonstrated by using a high-frequency electric field to trigger the first burst release of droplets with higher conductivity or thinner shell, followed by the second release of the other droplets under low-frequency electric field. The reported C-Fibers provide novel multidelivery system for a wide range of applications that require controlled release of multiple ingredients in a prescribed sequence.
在预定顺序中对多种包封剂进行单独共包封和选择性控制释放，在药物输送和组织工程中具有潜在的重要应用。然而，对于大多数现有的微载体，在一个触发事件下对不同内容物进行选择性控制释放仍然具有挑战性。本文提出了一种新颖的复合液滴对填充水凝胶微纤维（C-Fibers）的微流体制备方法，用于在交流电场下进行两步选择性控制释放。平行排列的复合液滴能够在单个微纤维中分别共包封不同的内容物，并且通过封装液滴的外壳厚度或芯导电性的差异来保证释放顺序。通过使用高频电场触发具有更高导电性或更薄外壳的液滴的第一次爆发式释放，然后在低频电场下释放另一个液滴，从而证明了这一点。所报道的 C-Fibers 为需要按规定顺序释放多种成分的广泛应用提供了新型的多输送系统。
