Department of Gastroenterology and Hepatology, Zhujiang Hospital of South Medical University, Guangzhou, China.
Department of Gastroenterology and Hepatology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
DNA Cell Biol. 2019 Nov;38(11):1338-1345. doi: 10.1089/dna.2019.4737. Epub 2019 Aug 29.
Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease, which often affects colon or rectum or both. It is now well recognized that sphingosine kinases-1/sphingosine-1-phosphate (S1P) signaling may have a very significant potential as targets for therapeutic intervention in UC. Compared with the pure dextran sodium sulfate group, administration of PF543 significantly reduced clinical symptoms with less weight loss, diarrhea, and shortening of the colon. The severity of colitis was improved with reduced disease activity index and degree of histological damage in colon. Moreover, treatment with PF543 not only decreased S1P but also inhibited mRNA expression of proinflammatory factors such as interleukin (IL)-1β and IL-6. This suggests that PF543 might exhibit an anti-inflammatory function against colitis through inhibition of expression of proinflammatory factors.
溃疡性结肠炎（UC）是一种慢性复发性炎症性肠病，常累及结肠或直肠，或两者皆累及。现在人们已经充分认识到，鞘氨醇激酶-1/鞘氨醇-1-磷酸（S1P）信号可能具有非常重要的治疗干预溃疡性结肠炎的潜力。与单纯的葡聚糖硫酸钠组相比，PF543 的给药显著减轻了临床症状，体重减轻、腹泻和结肠缩短的情况更少。通过降低疾病活动指数和结肠组织学损伤程度，改善了结肠炎的严重程度。此外，PF543 的治疗不仅降低了 S1P，还抑制了促炎因子如白细胞介素（IL）-1β和 IL-6 的 mRNA 表达。这表明 PF543 通过抑制促炎因子的表达可能对结肠炎具有抗炎作用。
