Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA; Cancer Center, Stony Brook University, Stony Brook, NY 11794, USA.
Cancer Center, Stony Brook University, Stony Brook, NY 11794, USA; Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11790, USA.
Cell Signal. 2021 Mar;79:109875. doi: 10.1016/j.cellsig.2020.109875. Epub 2020 Dec 5.
Sphingolipids and their synthetic enzymes have emerged as critical mediators in numerous diseases including inflammation, aging, and cancer. One enzyme in particular, sphingosine kinase (SK) and its product sphingosine-1-phosphate (S1P), has been extensively implicated in these processes. SK catalyzes the phosphorylation of sphingosine to S1P and exists as two isoforms, SK1 and SK2. In this review, we will discuss the contributions from the laboratory of Dr. Lina M. Obeid that have defined the roles for several bioactive sphingolipids in signaling and disease with an emphasis on her work defining SK1 in cellular fates and pathobiologies including proliferation, senescence, apoptosis, and inflammation.
鞘脂及其合成酶已成为多种疾病（包括炎症、衰老和癌症）的关键介质。特别是一种酶，即鞘氨醇激酶（SK）及其产物 1-磷酸鞘氨醇（S1P），已广泛涉及这些过程。SK 将鞘氨醇催化磷酸化为 S1P，存在两种同工酶，即 SK1 和 SK2。在这篇综述中，我们将讨论 Lina M. Obeid 博士实验室的研究成果，这些成果定义了几种生物活性鞘脂在信号转导和疾病中的作用，重点介绍了她在细胞命运和病理生物学（包括增殖、衰老、凋亡和炎症）中定义 SK1 的工作。
