Department of Maxillofacial Surgery and Oral Pathology, Amsterdam UMC and Academic Centre for Dentistry Amsterdam (ACTA), Vrije Universiteit Amsterdam, The Netherlands.
Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), Amsterdam, The Netherlands.
Clin Exp Rheumatol. 2019 May-Jun;37 Suppl 118(3):225-233. Epub 2019 Aug 28.
Sjögren's syndrome (SS) is an autoimmune disorder causing irreversible damage to the exocrine glands. Evidence whether SS patients are at a higher risk to develop periodontal disease is conflicting. Therefore, we systematically reviewed the literature on the prevalence of periodontal disease in patients with SS.
Searches were performed in MEDLINE and CENTRAL databases on prevalence of periodontal diseases in SS. Meta-analyses were performed for gingival index (GI), plaque index (PI), probing pocket depth (PPD), clinical attachment level (CAL), DMFT and DMFS (Decayed Missing Filled Teeth, respectively, Surfaces).
Out of 512 studies, 10 studies were eligible for quantitative synthesis. Meta-analyses of the data indicated that in SS patients CAL, GI, PPD and PI are comparable to controls. DMFT and DMFS values were higher in SS patients than controls.
No significant differences in the GI, PI, CAL, and PPD were observed in patients with SS compared to controls. These results indicate that there is no evidence of a higher risk for periodontal disease in patients with SS, while SS patients are more susceptible to caries compared to non-SS patients.
干燥综合征（SS）是一种自身免疫性疾病，可导致外分泌腺的不可逆损伤。SS 患者是否更容易患牙周病的证据存在争议。因此，我们系统地回顾了 SS 患者牙周病患病率的相关文献。
在 MEDLINE 和 CENTRAL 数据库中对 SS 患者牙周病的患病率进行了检索。对牙龈指数（GI）、菌斑指数（PI）、探诊袋深度（PPD）、临床附着丧失（CAL）、DMFT 和 DMFS（分别代表龋齿、缺失和补牙的牙齿数，受检牙面数）进行了荟萃分析。
在 512 项研究中，有 10 项研究符合定量综合分析的纳入标准。数据分析的荟萃分析结果表明，SS 患者的 CAL、GI、PPD 和 PI 与对照组无显著差异。SS 患者的 DMFT 和 DMFS 值高于对照组。
与对照组相比，SS 患者的 GI、PI、CAL 和 PPD 无显著差异。这些结果表明，SS 患者患牙周病的风险没有增加，但与非 SS 患者相比，SS 患者更容易患龋齿。
