aDepartment of Physiology, Jilin Medical University bDepartment of Biochemistry, Jilin Medical University cDepartment of Internal Medicine, Chinese PLA No. 222 Hospital dThe Department of Pathogenic Biology, Jilin Medical University, Jilin, China.
Neuroreport. 2019 Oct 16;30(15):993-997. doi: 10.1097/WNR.0000000000001309.
Although accumulating evidence suggests that there are significant anatomical and histological differences between the sulci and gyri of the cerebral cortex, whether there is a difference in the distribution of interneurons between the two cortical regions remains largely unknown. In this study, we systematically compared the distributions of parvalbumin-positive interneurons among three neighboring gyrus and sulcus pairs-coronal gyrus and cruciate sulcus, anterior ectosylvian gyrus and rostral suprasylvian sulcus, and posterior ectosylvian gyrus and pseudosylvian sulcus-in the adult ferret cerebral cortex. We proposed a method to partition sulci and gyri into several specific subregions through the deepest points of the sulci and the highest points of gyri in the inner and outer cortical contours of coronal sections. We found that the density of parvalbumin-positive interneurons in the gyri was significantly higher than that in the sulci. Further study revealed that the density of PV interneurons in superficial cortical layers (layers 2/3 and layer 4) was comparable among the three pairs of sulci and gyri. However, the density of parvalbumin-positive interneurons in cortical layers 5/6 was significantly higher in gyri than in sulci. These results indicate that parvalbumin-positive interneurons are differently distributed in infragranular layers of cortical sulci and gyri.
虽然越来越多的证据表明大脑皮质的脑回和脑沟在解剖学和组织学上存在显著差异，但这两个皮质区域之间的中间神经元分布是否存在差异仍知之甚少。在这项研究中，我们系统比较了成年雪貂大脑皮质中三个相邻脑回和脑沟对（冠状回和十字沟、前外侧裂回和额上外侧沟、后外侧裂回和假性外侧裂沟）之间的 PV 阳性中间神经元的分布。我们提出了一种通过冠状切片内外皮质轮廓的脑沟最深点和脑回最高点将脑沟和脑回划分为几个特定亚区的方法。我们发现脑回中的 PV 阳性中间神经元密度显著高于脑沟。进一步的研究表明，在三个脑沟和脑回对中，浅层皮质（第 2/3 层和第 4 层）中 PV 中间神经元的密度相当。然而，皮质 5/6 层中 PV 阳性中间神经元的密度在脑回中显著高于脑沟。这些结果表明，PV 阳性中间神经元在皮质脑沟和脑回的颗粒下层中的分布不同。
