Sawada Kazuhiko, Watanabe Misaki
Departments of Physical Therapy Nursing, Faculty of Medical and Health Sciences, Tsukuba International University, Tsuchiura, Ibaraki, Japan.
Congenit Anom (Kyoto). 2012 Sep;52(3):168-75. doi: 10.1111/j.1741-4520.2012.00372.x.
The present study aimed to clarify sulcation and gyration patterns in the developing cerebrum of ferrets. While the brain weight and fronto-occipital length of the cerebral hemisphere reached a plateau by postnatal day (PD) 42, the cerebral width reached a plateau at the rostral region by PD 21, and subsequently at the caudal region by PD 42. The ferret cerebrum already showed a convoluted surface with indentations of coronal and rostral suprasylvian sulci on PD 4. The presylvian and cruciate sulci emerged by PD 10, resulting in convolutions of gyri in the rostral half of the cerebrum. The caudal half of the cerebrum was infolded by the emergence of the pseudosylvian sulcus and the rhinal fissure by PD 10, and the caudal suprasylvian and lateral sulci by PD 21. The emergence of those sulci allowed a gyration in the caudal half of the cerebrum. Sexual differences in sulcation were detected by a more distinct convolution of the visual cortex in males than in females on PD 90. Those results, therefore, suggest that the ferret cerebrum experiences cortical maturation with sulcation and gyration in a rostrocaudal gradient manner. The present paper provides neuroanatomic references for normal development of cerebral sulci and gyri in both sexes of ferrets.
本研究旨在阐明雪貂发育中的大脑的脑沟和脑回模式。虽然大脑半球的脑重和额枕长度在出生后第42天达到稳定状态，但脑宽度在出生后第21天在脑前部区域达到稳定状态，随后在出生后第42天在脑后部区域达到稳定状态。雪貂大脑在出生后第4天就已经呈现出表面有脑回，伴有冠状沟和额上薛氏沟的凹陷。在出生后第10天，薛氏前沟和十字沟出现，导致大脑前半部分的脑回形成。在出生后第10天，大脑后半部分因假薛氏沟和嗅裂的出现而内折，在出生后第21天因后薛氏沟和外侧沟的出现而内折。这些脑沟的出现使得大脑后半部分形成脑回。在出生后第90天，通过雄性视觉皮层的脑回比雌性更明显，检测到脑沟形成的性别差异。因此，这些结果表明，雪貂大脑以头尾梯度方式通过脑沟和脑回经历皮质成熟。本文为雪貂两性大脑脑沟和脑回的正常发育提供了神经解剖学参考。
