强迫症遗传学的新见解与观点

New insights and perspectives on the genetics of obsessive-compulsive disorder.

作者信息

Zai Gwyneth, Barta Csaba, Cath Danielle, Eapen Valsamma, Geller Daniel, Grünblatt Edna

机构信息

Neurogenetics Section, Molecular Brain Science Department, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health Department of Psychiatry Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, ON, Canada Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary Groningen University and University Medical Center Groningen, Department of Psychiatry, The Netherlands Drenthe Mental Health Institute, Department of Specialist Training, The Netherlands Department of Psychiatry, University of New South Wales, Sydney, Australia & Academic Unit of Child Psychiatry South West Sydney, Ingham Institute and Liverpool Hospital, Sydney, Australia Massachusetts General Hospital and Harvard University Medical School, Boston, MA, USA Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Switzerland Neuroscience Center Zurich, University of Zurich and ETH Zurich, Switzerland Zurich Center for Integrative Human Physiology, University of Zurich, Switzerland.

出版信息

Psychiatr Genet. 2019 Oct;29(5):142-151. doi: 10.1097/YPG.0000000000000230.

DOI:10.1097/YPG.0000000000000230

PMID:31464995

Abstract

Psychiatric genetic research has exploded in search of polygenic risk factors over the past decade, but because of the complexity and heterogeneity of mental illnesses, using the current understanding of the genome has not reached the conclusion of finding a cause for psychiatric disorders. Obsessive-compulsive disorder is a relatively common and often debilitating neuropsychiatric disorder that has not been the primary focus in psychiatric research. Clinicians and researchers who have dedicated to investigate the genetics of obsessive-compulsive disorder have detected a strong genetic involvement. This review will provide an update and a new perspective on the current understanding of the genetics of obsessive-compulsive disorder, which includes epidemiological data, family and twins studies, candidate gene studies, genome-wide association studies, copy-number variants, imaging genetics, epigenetics, and gene-environment interaction.

摘要

在过去十年中，为寻找多基因风险因素，精神科遗传学研究蓬勃发展。但由于精神疾病的复杂性和异质性，基于目前对基因组的理解，尚未得出精神疾病病因的结论。强迫症是一种相对常见且往往使人衰弱的神经精神疾病，它并非精神科研究的主要焦点。致力于研究强迫症遗传学的临床医生和研究人员已发现其与遗传因素密切相关。本综述将为强迫症遗传学的当前理解提供更新内容和新视角，其中包括流行病学数据、家系和双生子研究、候选基因研究、全基因组关联研究、拷贝数变异、影像遗传学、表观遗传学以及基因 - 环境相互作用。