Sansonno D E, Fiore G, Pietropaolo F, Avellis D, Napoli N, Manghisi O G
Laboratory of Liver Immunopathology, Istituto di Ricovero e Cura a Carattere Scientifico, Castellana Grotte, Bari, Italy.
Digestion. 1988;39(4):197-203. doi: 10.1159/000199626.
Clinical course, morphologic changes, immunohistochemical localization of HBV-associated markers (HBsAg, HBcAg), and serum HBV-DNA production are described in 2 chronic HBsAg carriers superinfected with HAV and hepatitis non-A, non-B virus. Our data suggest that the superinfections do not cause more severe disease and do not influence the clinical course of the HBsAg chronic carriers. Our observations indicate that a careful diagnosis of hepatocytolysis is necessary in HBV chronic infection, in order to discriminate causes that are able to induce severe damage in underlying disease.
本文描述了2例慢性乙肝表面抗原（HBsAg）携带者重叠感染甲型肝炎病毒（HAV）及非甲非乙型肝炎病毒后的临床病程、形态学变化、乙肝相关标志物（HBsAg、HBcAg）的免疫组化定位以及血清乙肝病毒脱氧核糖核酸（HBV-DNA）的产生情况。我们的数据表明，重叠感染不会导致更严重的疾病，也不会影响HBsAg慢性携带者的临床病程。我们的观察结果表明，在乙肝慢性感染中，为了鉴别能够在基础疾病中引起严重损害的病因，有必要对肝细胞溶解进行仔细诊断。
