亚硝酸丁酯介导的氟化α-烷氧基肟醚衍生物的合成
-Butyl Nitrite Mediated Synthesis of Fluorinated -Alkyloxime Ether Derivatives.
作者信息
Ma Xingxing, Song Qiuling
机构信息
Institute of Next Generation Matter Transformation, College of Materials Science & Engineering , Huaqiao University , 668 Jimei Blvd , Xiamen , Fujian 361021 , China.
Key Laboratory of Molecule Synthesis and Function Discovery, Fujian Province University , College of Chemistry at Fuzhou University , Fuzhou , Fujian 350108 , China.
出版信息
Org Lett. 2019 Sep 20;21(18):7375-7379. doi: 10.1021/acs.orglett.9b02689. Epub 2019 Aug 29.
A -butyl nitrite (TBN)-mediated synthesis of fluorinated -alkyloxime ether derivatives with bromodifluoroalkyl reagents as the fluorine sources has been developed. A variety of halodifluorinated compounds were found compatible, delivering the desired products in moderate to excellent yields. This transformation features a simple operation, can be done in air, and found to involve radicals. This protocol represents a straightforward approach to access various fluorinated -alkyloxime ether derivatives.
已经开发了一种以亚硝酸叔丁酯（TBN）介导，以溴二氟烷基试剂作为氟源合成氟化α-烷氧基肟醚衍生物的方法。发现多种卤代二氟化合物具有兼容性，能以中等至优异的产率得到所需产物。这种转化操作简单，可以在空气中进行，并且发现涉及自由基。该方法是获得各种氟化α-烷氧基肟醚衍生物的直接途径。
Zotero 插件