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具有大成像深度的无校准时间拉伸光学相干断层扫描

Calibration-free time-stretch optical coherence tomography with large imaging depth.

作者信息

Zhang Lei, Chen Liao, Lei Zihui, Duan Yuhua, Zhang Chi, Zhang Xinliang

出版信息

Opt Lett. 2019 Sep 1;44(17):4135-4138. doi: 10.1364/OL.44.004135.

DOI:10.1364/OL.44.004135
PMID:31465347
Abstract

We demonstrate a calibration-free time-stretch optical coherence tomography (TS-OCT), based on an optical higher order dispersion compensation scheme, which substitutes the digital calibration with optical dispersion compensation. As a result, the acquired raw data can directly perform the Fourier transform, and data processing time is greatly reduced by 82%, compared with the digital calibration. Moreover, because of the high-sensitivity and calibration-free characteristics, the high-order dispersion compensation-based TS-OCT can increase sensitivity roll-off by 2.6 times to 6.91 mm/dB and effective imaging depth by 14.2% to 16 mm. The in vivo biological tissue imaging has been demonstrated, with the single-shot A-scan rate approaching 19 MHz. This higher order dispersion compensation scheme could provide a promising solution for the TS-OCT system to realize 3D imaging in real time and enhanced imaging quality.

摘要

我们展示了一种基于光学高阶色散补偿方案的免校准时间拉伸光学相干断层扫描(TS-OCT),该方案用光学色散补偿替代了数字校准。结果,采集到的原始数据可以直接进行傅里叶变换,与数字校准相比,数据处理时间大幅减少了82%。此外,由于具有高灵敏度和免校准特性,基于高阶色散补偿的TS-OCT可以将灵敏度滚降提高2.6倍,达到6.91毫米/分贝,并将有效成像深度提高14.2%,达到16毫米。已证明其能够对体内生物组织进行成像,单次A扫描速率接近19兆赫兹。这种高阶色散补偿方案可为TS-OCT系统实时实现三维成像和提高成像质量提供一个有前景的解决方案。

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