von Wichert P, Müller B, Meyer-Ingold W
Medizinische Poliklinik der Philipps Universität, Marburg/Lahn, Federal Republic of Germany.
Lung. 1988;166(5):257-67. doi: 10.1007/BF02714056.
Changes in surfactant function play an important part in the pathogenesis of adult respiratory distress syndrome (ARDS). Since beta-adrenergic agonists have been shown to exert a decisive influence on surfactant secretion, we studied the effect of fenoterol on lung phospholipid metabolism under conditions of experimental sepsis. Fenoterol administered to live rats increased the incorporation of choline into lung tissue by 80% in normal, by 35% in septic animals. It had no comparable effect on palmitate incorporation. It increased the activity of choline kinase in control animals, but had no additional effect on animals with increased values due to sepsis. Phosphotransferase activity diminished during sepsis was stimulated, and phospholipase activity reduced. Fenoterol restored phosphatidylcholine to normal levels in lung tissue and bronchoalveolar lavage and prevented lysophosphatidylcholine generation. Fenoterol also increased the amount of palmitate in phosphatidylcholine from bronchoalveolar lavage in septic animals. The results imply that a beta-adrenergic agonist influences the conditions of lung phospholipid metabolism altered by sepsis towards normal.
表面活性剂功能的改变在成人呼吸窘迫综合征（ARDS）的发病机制中起重要作用。由于β-肾上腺素能激动剂已被证明对表面活性剂分泌有决定性影响，我们研究了非诺特罗在实验性脓毒症条件下对肺磷脂代谢的影响。给存活大鼠注射非诺特罗后，正常大鼠肺组织中胆碱的掺入量增加了80%，脓毒症动物增加了35%。它对棕榈酸掺入没有类似作用。它增加了对照动物中胆碱激酶的活性，但对因脓毒症而值升高的动物没有额外影响。脓毒症期间降低的磷酸转移酶活性受到刺激，磷脂酶活性降低。非诺特罗使肺组织和支气管肺泡灌洗中的磷脂酰胆碱恢复到正常水平，并防止溶血磷脂酰胆碱的产生。非诺特罗还增加了脓毒症动物支气管肺泡灌洗中磷脂酰胆碱中棕榈酸的含量。结果表明，β-肾上腺素能激动剂可使脓毒症改变的肺磷脂代谢状况恢复正常。
