定义独特人类T细胞表面抗原的单克隆抗体。

Monoclonal antibodies defining distinctive human T cell surface antigens.

作者信息

Kung P, Goldstein G, Reinherz E L, Schlossman S F

出版信息

Science. 1979 Oct 19;206(4416):347-9. doi: 10.1126/science.314668.

Abstract

Three novel nonoclonal antibodies (designed OKT1, OKT3, and OKT4) were generated against surface determinants of human peripheral T cells. Both OKT1 and OKT3 reacted with all human peripheral T cells and 5 to 10 percent of thymocytes but differed in their reactivities with T cel- lines. By contrast, OKT4 reacted with 55 percent of human peripheral T cells and 80 percent of thymocyted in that they did not react with normal B cells, null cells, monocytes, or granulocytes.

摘要

针对人外周血T细胞的表面决定簇产生了三种新型单克隆抗体（分别设计为OKT1、OKT3和OKT4）。OKT1和OKT3均与所有人外周血T细胞以及5%至10%的胸腺细胞发生反应，但它们与T细胞系的反应性有所不同。相比之下，OKT4与55%的人外周血T细胞和80%的胸腺细胞发生反应，因为它们不与正常B细胞、裸细胞、单核细胞或粒细胞发生反应。