Saku K, Mendoza S G, Laver M, Hynd B A, Gartside P S, Kashyap M L
Department of Internal Medicine, University of Cincinnati Medical Center, Ohio.
Nephron. 1988;50(2):112-5. doi: 10.1159/000185139.
The kinetic parameters of high-density lipoprotein (HDL) and its major apolipoproteins (Apo) AI and Apo AII were studied in 2 patients with moderate and severe proteinuria and 2 normal controls after intravenous injection of autologous 125I-HDL. The fractional catabolic rates (FCR) of HDL estimated by urine/plasma radioactivity ratio, and FCR of Apo AI and Apo AII calculated from the radioactivity decay curves were higher in the patients. These results support the concept that high-density lipoproteinuria and renal parenchymal sequestration of HDL found in the nephrotic syndrome contribute to accelerated HDL catabolism.
对2例中度和重度蛋白尿患者及2名正常对照者静脉注射自体125I - 高密度脂蛋白（HDL）后，研究了HDL及其主要载脂蛋白（Apo）AI和Apo AII的动力学参数。通过尿/血浆放射性比值估算的HDL分解代谢率（FCR），以及根据放射性衰变曲线计算的Apo AI和Apo AII的FCR在患者中较高。这些结果支持了以下概念，即肾病综合征中发现的高密度脂蛋白尿和HDL在肾实质中的潴留导致HDL分解代谢加速。
