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Early high plasma ST2, the decoy IL-33 receptor, in children undergoing hematopoietic cell transplantation is associated with the development of post-transplant diabetes mellitus.

作者信息

Rowan Courtney M, Teagarden Alicia M, Cater Daniel T, Moser Elizabeth A S, Baykoyannis Giorgos, Paczesny Sophie

机构信息

Department of Pediatrics, Indiana University School of Medicine

Department of Pediatrics, Indiana University School of Medicine.

出版信息

Haematologica. 2020 May;105(5):e249-e252. doi: 10.3324/haematol.2019.222992. Epub 2019 Aug 29.

DOI:10.3324/haematol.2019.222992
PMID:31467129
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7193497/
Abstract
摘要

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1
Early high plasma ST2, the decoy IL-33 receptor, in children undergoing hematopoietic cell transplantation is associated with the development of post-transplant diabetes mellitus.造血细胞移植患儿早期血浆中高水平的可溶性ST2（诱饵型白细胞介素-33受体）与移植后糖尿病的发生有关。
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2
Soluble interleukin-27 receptor alpha is a valuable prognostic biomarker for acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation.可溶性白细胞介素-27 受体 α 是异基因造血干细胞移植后急性移植物抗宿主病的有价值的预后生物标志物。
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[Significance of ST2 in the Early Diagnosis and Treatment of Graft-Versus-Host Disease--Review].[ST2在移植物抗宿主病早期诊断与治疗中的意义——综述]
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IL-6 and IL-8 levels in plasma during hematopoietic progenitor transplantation.造血祖细胞移植期间血浆中的白细胞介素-6和白细胞介素-8水平。
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Effect of β-Blocker Therapy on the Level of Soluble ST2 Protein in Pediatric Dilated Cardiomyopathy.β受体阻滞剂治疗对小儿扩张型心肌病可溶性 ST2 蛋白水平的影响。
Medicina (Kaunas). 2022 Sep 23;58(10):1339. doi: 10.3390/medicina58101339.
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New-onset post-transplant diabetes mellitus after haploidentical hematopoietic cell transplant with post-transplant cyclophosphamide.单倍体造血细胞移植联合移植后环磷酰胺治疗后新发移植后糖尿病
EJHaem. 2020 Nov;1(2):576-580. doi: 10.1002/jha2.70. Epub 2020 Sep 23.
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Soluble Suppression of Tumorigenicity 2 is Directly Correlated with Glycated Hemoglobin in Individuals with an Average glycemia in the Normal/Prediabetes Range.在血糖处于正常/糖尿病前期范围的个体中，可溶性肿瘤抑制因子2与糖化血红蛋白直接相关。
Diabetes Metab Syndr Obes. 2020 Aug 3;13:2711-2718. doi: 10.2147/DMSO.S251135. eCollection 2020.
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Post-haematopoietic cell transplantation outcomes: why ST2 became a 'golden nugget' biomarker.造血细胞移植后结局：为何 ST2 成为“金标准”生物标志物。
Br J Haematol. 2021 Mar;192(6):951-967. doi: 10.1111/bjh.16497. Epub 2020 Feb 10.

本文引用的文献

1
New-Onset Post-Transplant Diabetes Mellitus after Allogeneic Hematopoietic Cell Transplant Is Initiated by Insulin Resistance, Not Immunosuppressive Medications.异基因造血细胞移植后新发移植后糖尿病的发生是由胰岛素抵抗引起的，而不是免疫抑制药物。
Biol Blood Marrow Transplant. 2019 Jun;25(6):1225-1231. doi: 10.1016/j.bbmt.2019.02.001. Epub 2019 Feb 7.
2
Metabolic Complications Precede Alloreactivity and Are Characterized by Changes in Suppression of Tumorigenicity 2 Signaling.代谢并发症先于同种异体反应性出现，并以致瘤性2信号抑制的变化为特征。
Biol Blood Marrow Transplant. 2017 Mar;23(3):529-532. doi: 10.1016/j.bbmt.2016.12.627. Epub 2016 Dec 21.
3
Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes.炎症作为肥胖、代谢综合征和 2 型糖尿病之间的联系。
Diabetes Res Clin Pract. 2014 Aug;105(2):141-50. doi: 10.1016/j.diabres.2014.04.006. Epub 2014 Apr 13.
4
ST2 as a marker for risk of therapy-resistant graft-versus-host disease and death.ST2 可作为治疗抵抗性移植物抗宿主病和死亡的标志物。
N Engl J Med. 2013 Aug 8;369(6):529-39. doi: 10.1056/NEJMoa1213299.
5
Toll/interleukin-1 receptor member ST2 exhibits higher soluble levels in type 2 diabetes, especially when accompanied with left ventricular diastolic dysfunction.Toll/白介素-1 受体成员 ST2 的可溶性水平在 2 型糖尿病中较高，尤其是伴有左心室舒张功能障碍时。
Cardiovasc Diabetol. 2011 Nov 21;10:101. doi: 10.1186/1475-2840-10-101.
6
Pretransplantation C-Peptide level predicts early posttransplantation diabetes mellitus and has an impact on survival after allogeneic stem cell transplantation.移植前 C 肽水平可预测移植后早期糖尿病，并对异基因干细胞移植后的生存产生影响。
Biol Blood Marrow Transplant. 2011 Jan;17(1):86-92. doi: 10.1016/j.bbmt.2010.06.010. Epub 2010 Jun 16.
7
Hyperglycemia during the neutropenic period is associated with a poor outcome in patients undergoing myeloablative allogeneic hematopoietic stem cell transplantation.在接受清髓性异基因造血干细胞移植的患者中，中性粒细胞减少期的高血糖与不良预后相关。
Transplantation. 2007 Oct 15;84(7):814-20. doi: 10.1097/01.tp.0000296482.50994.1c.
8
Adverse clinical consequences of hyperglycemia from total parenteral nutrition exposure during hematopoietic stem cell transplantation.造血干细胞移植期间全肠外营养暴露导致高血糖的不良临床后果。
Biol Blood Marrow Transplant. 2006 Jun;12(6):656-64. doi: 10.1016/j.bbmt.2006.01.010.