Mts1 上调与甲状腺癌侵袭性病理特征相关。
Mts1 Up-regulation is Associated With Aggressive Pathological Features in Thyroid Cancer.
机构信息
Department of Biochemistry, College of Medicine, Gachon University, Incheon, Republic of Korea.
Department of Surgery, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea.
出版信息
Cancer Genomics Proteomics. 2019 Sep-Oct;16(5):369-376. doi: 10.21873/cgp.20142.
BACKGROUND/AIM: Thyroid cancer is the most common type of endocrine cancer and its incidence and mortality are increasing. However, few studies on the molecular factors related to its poor prognosis have been performed. The aim of our study was to identify a poor prognostic factor for thyroid cancer to reduce its overtreatment, recurrence, and mortality.
MATERIALS AND METHODS
The present study is a retrospective study of 55 patients who were diagnosed with papillary thyroid cancer and operated in Korea from September 2013 to November 2015.
RESULTS
Mts1 is a member of the S100 protein family and is involved in tumor progression and metastasis. Mts1 was highly expressed in patients with thyroid cancer and high Mts1 levels were related to poor prognoses such as lymph node metastasis.
CONCLUSION
Mts1 is associated with aggressive pathological features in thyroid cancer, and may be a poor prognostic factor for thyroid cancer.
背景/目的：甲状腺癌是最常见的内分泌系统癌症，其发病率和死亡率正在上升。然而，针对与预后不良相关的分子因素的研究较少。本研究旨在确定甲状腺癌的预后不良因素，以减少过度治疗、复发和死亡。
材料和方法
本研究为回顾性研究，纳入 2013 年 9 月至 2015 年 11 月在韩国诊断为甲状腺乳头状癌并接受手术的 55 例患者。
结果
Mts1 是 S100 蛋白家族的成员，参与肿瘤的进展和转移。Mts1 在甲状腺癌患者中高表达，高水平的 Mts1 与淋巴结转移等不良预后相关。
结论
Mts1 与甲状腺癌侵袭性病理特征相关，可能是甲状腺癌的预后不良因素。
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