Fei Fei, Qu Jie, Zhang Mingqing, Li Yuwei, Zhang Shiwu
Nankai University School of Medicine, Nankai University, Tianjin, 300071, P.R.China.
Department of Pathology, Tianjin Union Medical Center, Tianjin, 300121, P.R. China.
Oncotarget. 2017 May 19;8(42):73219-73239. doi: 10.18632/oncotarget.18016. eCollection 2017 Sep 22.
Metastasis is the leading cause of cancer-related death and directly associates with cancer progression, resistance to anticancer therapy, and poor patient survival. Current efforts focusing on the underlying molecular mechanisms of cancer metastasis attract a special attention to cancer researchers. The epithelial-mesenchymal transition is a complex of molecular program during embryogenesis, inflammation, tissue fibrosis, and cancer progression and metastasis. S100A4, an important member of S100 family proteins, functions to increase the tumor progression and metastasis. The molecular mechanisms of S100A4 involving in the progression and metastasis are diverse in various malignant tumors. Detection of S100A4 expression becomes a promising candidate biomarker in cancer early diagnosis and prediction of cancer metastasis and therefore, S100A4 may be a therapeutic target. This review summarized up to date advancement on the role of S100A4 in human cancer development, progression, and metastasis and the underlying molecular events and then strategies to target S100A4 expression experimentally.
转移是癌症相关死亡的主要原因，与癌症进展、抗癌治疗耐药性以及患者生存率低直接相关。目前针对癌症转移潜在分子机制的研究工作引起了癌症研究人员的特别关注。上皮-间质转化是胚胎发育、炎症、组织纤维化以及癌症进展和转移过程中的一个复杂分子程序。S100A4是S100家族蛋白的重要成员，具有促进肿瘤进展和转移的作用。S100A4参与进展和转移的分子机制在各种恶性肿瘤中各不相同。检测S100A4表达成为癌症早期诊断和预测癌症转移的一个有前景的候选生物标志物，因此，S100A4可能是一个治疗靶点。本综述总结了S100A4在人类癌症发生、进展和转移中的作用以及潜在分子事件的最新进展，然后介绍了通过实验靶向S100A4表达的策略。
