Choi You Jin, Jeong Su Jin
Department of Pediatrics, Inje University Ilsan Paik Hospital, Goyang, Korea.
Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.
Intest Res. 2019 Oct;17(4):546-553. doi: 10.5217/ir.2019.00009. Epub 2019 Sep 4.
BACKGROUND/AIMS: Fecal calprotectin (FC) is a marker of intraluminal intestinal inflammation. Intestinal inflammation may contribute to the pathophysiology of irritable bowel syndrome (IBS). This study evaluated FC levels in children with IBS and differences in FC levels in children stratified by IBS subtype and healthy controls (HCs).
A total of 157 children with IBS and 56 HCs aged 4-16 years (119 boys, 94 girls, mean age of 9.48 years) were included in this prospective study. Children with IBS were diagnosed using the Rome III criteria and classified into 4 subtypes: IBS with constipation (IBS-C, n=37), IBS with diarrhea (IBS-D, n=54), IBS with alternating constipation and diarrhea (IBS-M, n=49), and IBS unsubtyped (IBS-U, n=17); postinfectious IBS (PI-IBS) was also considered. The FC concentration in stool samples was analyzed using an enzyme-linked immunosorbent assay. All participants answered a questionnaire regarding several demographic and clinical characteristics.
Children with IBS had significantly higher levels of FC than the HCs (88.71 μg/g vs. 17.77 μg/g). Among the 4 IBS subtypes, the FC concentration was highest in children with IBS-D, followed by those with IBS-M, IBS-C, and IBS-U (169.94 μg/g vs. 45.04, 31.22, and 33.52 μg/g, respectively), and these differences were statistically significant. For PI-IBS, 90% of cases were in the IBS-D group.
The FC level was significantly higher in children with IBS than in HCs and differed depending on the IBS subtype, supporting the notion that IBS is a type of low-grade bowel inflammation.
背景/目的：粪便钙卫蛋白（FC）是肠腔内肠道炎症的标志物。肠道炎症可能参与肠易激综合征（IBS）的病理生理过程。本研究评估了IBS患儿的FC水平，以及按IBS亚型分层的患儿与健康对照（HC）之间FC水平的差异。
本前瞻性研究纳入了157例4 - 16岁的IBS患儿和56例HC（119例男孩，94例女孩，平均年龄9.48岁）。IBS患儿根据罗马III标准进行诊断，并分为4个亚型：便秘型IBS（IBS - C，n = 37）、腹泻型IBS（IBS - D，n = 54）、混合型IBS（IBS - M，n = 49）和未分型IBS（IBS - U，n = 17）；感染后IBS（PI - IBS）也纳入考虑。采用酶联免疫吸附测定法分析粪便样本中的FC浓度。所有参与者均回答了一份关于若干人口统计学和临床特征的问卷。
IBS患儿的FC水平显著高于HC（88.71μg/g对17.77μg/g）。在4种IBS亚型中，FC浓度在IBS - D患儿中最高，其次是IBS - M、IBS - C和IBS - U患儿（分别为169.94μg/g对45.04、31.22和33.
52μg/g），这些差异具有统计学意义。对于PI - IBS，90%的病例在IBS - D组。
IBS患儿的FC水平显著高于HC，且因IBS亚型而异，支持IBS是一种低度肠道炎症的观点。
