Can J Gastroenterol Hepatol. 2015 Apr;29(3):157-63. doi: 10.1155/2015/950286.
Given the number of inflammatory disorders affecting the gastrointestinal tract directly and indirectly, coupled with the considerable overlap with functional disorders, it is evident that more useful noninvasive diagnostic tests are required to aid with diagnosis. If these tests can also have some utility for individual patient follow-up in terms of disease activity and response to treatment, as well as providing forewarning of disease relapse, it would be extremely useful information for the clinician. One recently described test that may fulfill several of these attributes is based on leakage of a mononuclear cell cytoplasmic protein, calprotectin, along the intestinal tract, which can then be quantified in feces. This has been used to distinguish patients exhibiting symptoms of irritable bowel syndrome from patients with inflammatory bowel disease, with a measure of success greater than with currently used techniques. The present article summarizes the experience with this test used in inflammatory bowel disease, as well as a variety of gastrointestinal disorders.
鉴于有许多直接或间接影响胃肠道的炎症性疾病，加上与功能性疾病有很大的重叠，显然需要更有用的非侵入性诊断测试来辅助诊断。如果这些测试还可以在疾病活动和治疗反应方面为个别患者的随访提供一些效用，并为疾病复发提供预警，那么这对临床医生来说将是非常有用的信息。最近描述的一种测试可能符合其中的几个属性，该测试基于单核细胞细胞质蛋白钙卫蛋白沿着肠道的渗漏，然后可以在粪便中定量。该测试已被用于区分表现出肠易激综合征症状的患者和炎症性肠病患者，其成功率高于目前使用的技术。本文总结了该测试在炎症性肠病以及各种胃肠道疾病中的应用经验。
