Tura S, Finelli C, Bandini G, Cavo M, Gobbi M
Institute of Haematology L. e A. Serágnoli, University of Bologna, Italy.
Nouv Rev Fr Hematol (1978). 1988;30(5-6):479-81.
Three patients (1 PRCA-T-CLL, 1 PRCA-B-CLL, 1 B-CLL aplasia) were treated with cyclosporin A (CS-A). Patient no 1 had relapsed during steroid therapy and the remaining two patients had been resistant to conventional immunosuppression. CS-A produced in all cases a prompt remission (within 1-4 weeks) of bone marrow failure. Mild reversible renal toxicity was the only side-effect noted. CS-A might be tried in every case of CLL-associated bone marrow failure.
三名患者（1例纯红细胞再生障碍性贫血合并T细胞慢性淋巴细胞白血病，1例纯红细胞再生障碍性贫血合并B细胞慢性淋巴细胞白血病，1例B细胞慢性淋巴细胞白血病伴再生障碍）接受了环孢素A（CS-A）治疗。1号患者在类固醇治疗期间复发，其余两名患者对传统免疫抑制治疗耐药。CS-A在所有病例中均使骨髓衰竭迅速缓解（1-4周内）。仅观察到轻度可逆性肾毒性这一副作用。对于慢性淋巴细胞白血病相关的骨髓衰竭病例，均可尝试使用CS-A。
