环孢素A治疗慢性淋巴细胞白血病相关的纯红细胞再生障碍性贫血和骨髓发育不全
Cyclosporin A in the treatment of CLL associated PRCA and bone marrow hypoplasia.
作者信息
Tura S, Finelli C, Bandini G, Cavo M, Gobbi M
机构信息
Institute of Haematology L. e A. Serágnoli, University of Bologna, Italy.
出版信息
Nouv Rev Fr Hematol (1978). 1988;30(5-6):479-81.
Three patients (1 PRCA-T-CLL, 1 PRCA-B-CLL, 1 B-CLL aplasia) were treated with cyclosporin A (CS-A). Patient no 1 had relapsed during steroid therapy and the remaining two patients had been resistant to conventional immunosuppression. CS-A produced in all cases a prompt remission (within 1-4 weeks) of bone marrow failure. Mild reversible renal toxicity was the only side-effect noted. CS-A might be tried in every case of CLL-associated bone marrow failure.
三名患者（1例纯红细胞再生障碍性贫血合并T细胞慢性淋巴细胞白血病，1例纯红细胞再生障碍性贫血合并B细胞慢性淋巴细胞白血病，1例B细胞慢性淋巴细胞白血病伴再生障碍）接受了环孢素A（CS-A）治疗。1号患者在类固醇治疗期间复发，其余两名患者对传统免疫抑制治疗耐药。CS-A在所有病例中均使骨髓衰竭迅速缓解（1-4周内）。仅观察到轻度可逆性肾毒性这一副作用。对于慢性淋巴细胞白血病相关的骨髓衰竭病例，均可尝试使用CS-A。
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