Hjalmar V, Carlsson M, Kimby E
Department of Medicine, County Hospital Ryhov, Jönköping, Sweden.
Med Oncol. 1996 Jun;13(2):95-101. doi: 10.1007/BF02993859.
We have studied retrospectively patients with chronic lymphocytic leukaemia (CLL), at Ryhov, Jönköping, Sweden during a 10-year-period. This unselected cohort (n = 59) from a well-defined geographical area is suitable for describing the natural course of the disease. The CLL was diagnosed incidentally in the majority of cases. Median-age at diagnosis was 71 years and the male:female ratio was 1.3:1. The diagnosis was based on morphology in 66% and in 33% immunophenotyping specified the diagnosis of B- or T-CLL. At diagnosis 66% were in Rai-stage O/I or Binet-stage A. There were 36% untreated patients and their median-survival was 108 months compared with 84 months for the whole cohort and 72 months for the treated patients. Malignancies were seen in 31% and infections in 83%. Intercurrent diseases played an important role in the survival. During the observation time, only 54% of the deceased patients had died due to the CLL.
我们对瑞典延雪平里霍夫地区10年间慢性淋巴细胞白血病（CLL）患者进行了回顾性研究。这个来自明确地理区域的非选择性队列（n = 59）适合描述该疾病的自然病程。大多数病例的CLL是偶然诊断出来的。诊断时的中位年龄为71岁，男女比例为1.3:1。66%的诊断基于形态学，33%通过免疫表型分析明确诊断为B细胞或T细胞CLL。诊断时，66%处于 Rai 分期O/I 或 Binet 分期A。36%为未治疗患者，其中位生存期为108个月，而整个队列的中位生存期为84个月，治疗患者的中位生存期为72个月。31%的患者出现恶性肿瘤，83%的患者出现感染。并发疾病在生存中起重要作用。在观察期内，只有54%的死亡患者死于CLL。
