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本文引用的文献

1
Intraoral stents in preventing adverse radiotherapeutic effects in lip cancer patients.口腔内支架预防唇癌患者放疗不良反应的研究
Rep Pract Oncol Radiother. 2017 Nov-Dec;22(6):450-454. doi: 10.1016/j.rpor.2017.08.003. Epub 2017 Sep 1.
2
Utility of intraoral stents in external beam radiotherapy for head and neck cancer.口腔内支架在头颈部癌外照射放疗中的应用
Rep Pract Oncol Radiother. 2017 Jul-Aug;22(4):310-318. doi: 10.1016/j.rpor.2017.03.002. Epub 2017 May 8.
3
Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015: A Systematic Analysis for the Global Burden of Disease Study.全球、区域和国家癌症发病率、死亡率、生命损失年数、失能生存年数以及 32 种癌症组别的伤残调整生命年数,1990 年至 2015 年:全球疾病负担研究的系统分析。
JAMA Oncol. 2017 Apr 1;3(4):524-548. doi: 10.1001/jamaoncol.2016.5688.
4
Effectiveness of Positioning Stents in Radiation-Induced Xerostomia in Patients with Tongue Carcinoma: A Randomized Controlled Trial.定位支架治疗舌癌患者放射性口干的有效性:一项随机对照试验
Int J Prosthodont. 2016 Sep-Oct;29(5):455-60. doi: 10.11607/ijp.4499.
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The Effect of a Radiation Positioning Stent (RPS) in the Reduction of Radiation Dosage to the Opposing Jaw and Maintenance of Mouth opening after Radiation Therapy.放射定位支架(RPS)对减少放疗时对侧颌骨辐射剂量及放疗后维持张口度的影响。
Eur J Prosthodont Restor Dent. 2016 Jun;24(2):71-7.
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A pilot study to evaluate the efficacy of cerrobend shielding stents in preventing adverse radiotherapeutic effects in buccal carcinoma patients.一项评估塞罗班德屏蔽支架预防颊癌患者放疗不良反应疗效的初步研究。
J Cancer Res Ther. 2016 Jan-Mar;12(1):314-7. doi: 10.4103/0973-1482.154015.
7
Dosimetric impact of dental metallic crown on intensity-modulated radiotherapy and volumetric-modulated arc therapy for head and neck cancer.牙科金属冠对头部和颈部癌症调强放射治疗及容积调强弧形治疗的剂量学影响。
J Appl Clin Med Phys. 2016 Jan 8;17(1):234-245. doi: 10.1120/jacmp.v17i1.5870.
8
Prognoses and improvement for head and neck cancers diagnosed in Europe in early 2000s: The EUROCARE-5 population-based study.21世纪初在欧洲诊断出的头颈癌的预后与改善情况:基于人群的EUROCARE-5研究
Eur J Cancer. 2015 Oct;51(15):2130-2143. doi: 10.1016/j.ejca.2015.07.043. Epub 2015 Sep 26.
9
CT-based delineation of organs at risk in the head and neck region: DAHANCA, EORTC, GORTEC, HKNPCSG, NCIC CTG, NCRI, NRG Oncology and TROG consensus guidelines.基于CT对头颈部区域危及器官的勾画:DAHANCA、欧洲癌症研究与治疗组织(EORTC)、法国头颈肿瘤研究组(GORTEC)、香港鼻咽癌协作组(HKNPCSG)、加拿大国家癌症研究所临床试验组(NCIC CTG)、英国国家癌症研究所(NCRI)、美国国立综合癌症网络肿瘤学(NRG Oncology)和澳大利亚和新西兰放射肿瘤学组(TROG)共识指南
Radiother Oncol. 2015 Oct;117(1):83-90. doi: 10.1016/j.radonc.2015.07.041. Epub 2015 Aug 13.
10
Technical guidelines for head and neck cancer IMRT on behalf of the Italian association of radiation oncology - head and neck working group.代表意大利放射肿瘤学会头颈工作组发布的头颈癌调强放射治疗技术指南
Radiat Oncol. 2014 Dec 29;9:264. doi: 10.1186/s13014-014-0264-9.

在头颈部癌的高剂量适形放疗时代,口腔定制支架是否仍然必要?病例系列及文献综述。

Are intraoral customized stents still necessary in the era of Highly Conformal Radiotherapy for Head & Neck cancer? Case series and literature review.

作者信息

Appendino P, Della Ferrera F, Nassisi D, Blandino G, Gino E, Solla S D, Ruo Redda M G

机构信息

Department of Dentistry and Oral Surgery, Mauriziano Umberto I Hospital, Corso Turati 62, 10128 Turin, Italy.

Department of Radiation Oncology, University of Turin School of Medicine, Mauriziano Umberto I Hospital, Corso Turati 62, 10128 Turin, Italy.

出版信息

Rep Pract Oncol Radiother. 2019 Sep-Oct;24(5):491-498. doi: 10.1016/j.rpor.2019.07.012. Epub 2019 Aug 20.

DOI:10.1016/j.rpor.2019.07.012
PMID:31467490
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6710640/
Abstract

AIM

To evaluate the dose sparing efficacy of intraoral customized stents in combination with IGRT/VMAT in Head & Neck cancer patients.

BACKGROUND

Despite advances in high-dose conformal radiotherapy (RT) techniques, adverse effects (such as oral mucositis) during and after RT often require temporary suspension of treatment and affect the quality of life in survivors. Intraoral customized stents can decrease radiation doses in healthy tissues and minimize damage from radiations. At the best of our knowledge the clinical impact of such devices in combination with VMAT (volumetric modulated arc therapy) is not reported in the literature.

CASES DESCRIPTION

Three Head & Neck cancer patients were submitted to image guided (IG) RT/VMAT in their treatment protocol. Dose distribution with and without the use of an intraoral stent was compared in each patient. Mean radiation doses proved to be lower in all patients, especially in the subsite: oral cavity.

CONCLUSIONS

There are several reports on the efficacy of IS during RT for Head & Neck cancer. Despite technological advances, the combination between high conformal RT and intraoral stents could still play a role in the management of this kind of patients. This strengthens the usefulness of the individualization of treatments and multidisciplinary approach.

摘要

目的

评估口腔定制支架联合影像引导放射治疗(IGRT)/容积调强弧形放疗(VMAT)在头颈部癌患者中的剂量节省疗效。

背景

尽管高剂量适形放疗(RT)技术取得了进展,但放疗期间及放疗后的不良反应(如口腔黏膜炎)常常需要暂时中断治疗,并影响幸存者的生活质量。口腔定制支架可以降低健康组织的辐射剂量,并将辐射损伤降至最低。据我们所知,此类装置联合VMAT(容积调强弧形放疗)的临床影响在文献中尚无报道。

病例描述

3名头颈部癌患者在其治疗方案中接受了影像引导(IG)RT/VMAT。比较了每位患者使用和不使用口腔支架时的剂量分布。结果显示,所有患者的平均辐射剂量均较低,尤其是在口腔亚部位。

结论

关于口腔支架在头颈部癌放疗期间的疗效已有多篇报道。尽管技术不断进步,但高适形放疗与口腔支架的联合应用在这类患者的治疗中仍可发挥作用。这进一步证明了个体化治疗和多学科方法的有效性。