Appendino P, Della Ferrera F, Nassisi D, Blandino G, Gino E, Solla S D, Ruo Redda M G
Department of Dentistry and Oral Surgery, Mauriziano Umberto I Hospital, Corso Turati 62, 10128 Turin, Italy.
Department of Radiation Oncology, University of Turin School of Medicine, Mauriziano Umberto I Hospital, Corso Turati 62, 10128 Turin, Italy.
Rep Pract Oncol Radiother. 2019 Sep-Oct;24(5):491-498. doi: 10.1016/j.rpor.2019.07.012. Epub 2019 Aug 20.
To evaluate the dose sparing efficacy of intraoral customized stents in combination with IGRT/VMAT in Head & Neck cancer patients.
Despite advances in high-dose conformal radiotherapy (RT) techniques, adverse effects (such as oral mucositis) during and after RT often require temporary suspension of treatment and affect the quality of life in survivors. Intraoral customized stents can decrease radiation doses in healthy tissues and minimize damage from radiations. At the best of our knowledge the clinical impact of such devices in combination with VMAT (volumetric modulated arc therapy) is not reported in the literature.
Three Head & Neck cancer patients were submitted to image guided (IG) RT/VMAT in their treatment protocol. Dose distribution with and without the use of an intraoral stent was compared in each patient. Mean radiation doses proved to be lower in all patients, especially in the subsite: oral cavity.
There are several reports on the efficacy of IS during RT for Head & Neck cancer. Despite technological advances, the combination between high conformal RT and intraoral stents could still play a role in the management of this kind of patients. This strengthens the usefulness of the individualization of treatments and multidisciplinary approach.
评估口腔定制支架联合影像引导放射治疗(IGRT)/容积调强弧形放疗(VMAT)在头颈部癌患者中的剂量节省疗效。
尽管高剂量适形放疗(RT)技术取得了进展,但放疗期间及放疗后的不良反应(如口腔黏膜炎)常常需要暂时中断治疗,并影响幸存者的生活质量。口腔定制支架可以降低健康组织的辐射剂量,并将辐射损伤降至最低。据我们所知,此类装置联合VMAT(容积调强弧形放疗)的临床影响在文献中尚无报道。
3名头颈部癌患者在其治疗方案中接受了影像引导(IG)RT/VMAT。比较了每位患者使用和不使用口腔支架时的剂量分布。结果显示,所有患者的平均辐射剂量均较低,尤其是在口腔亚部位。
关于口腔支架在头颈部癌放疗期间的疗效已有多篇报道。尽管技术不断进步,但高适形放疗与口腔支架的联合应用在这类患者的治疗中仍可发挥作用。这进一步证明了个体化治疗和多学科方法的有效性。