Michalska M, Mirowski M, Wierzbicki R
Department of Biochemistry, Institute of Environmental Research and Bioanalysis, Lódź, Poland.
Pol J Pharmacol Pharm. 1988 Jul-Aug;40(4):365-71.
The effect of mercuric chloride on blood coagulation and fibrinolysis in rats was studied. The mercurial was administered to the animals intragastrically in a single dose of 17.9 mg Hg/kg and the effects were tested on the 1st, 3rd and 7th day. The symptoms of hypercoagulability accompanied by decreased fibrinolytic activity of the plasma were observed in the poisoned rats. The main reason of the lowered fibrinolytic activity seemed to be the inhibition of plasma plasminogen activator or the inhibition of plasminogen activation reaction catalyzed by this enzyme.
研究了氯化汞对大鼠血液凝固和纤维蛋白溶解的影响。以17.9毫克汞/千克的单剂量通过胃内给药的方式将汞制剂给予动物，并在第1、3和7天测试其效果。在中毒大鼠中观察到了伴有血浆纤维蛋白溶解活性降低的高凝症状。纤维蛋白溶解活性降低的主要原因似乎是血浆纤溶酶原激活剂受到抑制，或者是该酶催化的纤溶酶原激活反应受到抑制。
