Waldron Nathan H, Fudim Marat, Mathew Joseph P, Piccini Jonathan P
Department of Anesthesia, Duke University Medical Center, Durham, North Carolina.
Duke Clinical Research Institute, Durham, North Carolina.
JACC Basic Transl Sci. 2019 Aug 26;4(4):546-562. doi: 10.1016/j.jacbts.2019.02.009. eCollection 2019 Aug.
There is an increasing recognition of the importance of interactions between the heart and the autonomic nervous system in the pathophysiology of arrhythmias. These interactions play a role in both the initiation and maintenance of arrhythmias and are important in both atrial and ventricular arrhythmia. Given the importance of the autonomic nervous system in the pathophysiology of arrhythmias, there has been notable effort in the field to improve existing therapies and pioneer additional interventions directed at cardiac-autonomic targets. The interventions are targeted to multiple and different anatomic targets across the neurocardiac axis. The purpose of this review is to provide an overview of the rationale for neuromodulation in the treatment of arrhythmias and to review the specific treatments under evaluation and development for the treatment of both atrial fibrillation and ventricular arrhythmias.
心脏与自主神经系统之间的相互作用在心律失常的病理生理学中的重要性日益得到认可。这些相互作用在心律失常的起始和维持中均发挥作用，并且在房性和室性心律失常中都很重要。鉴于自主神经系统在心律失常病理生理学中的重要性，该领域已做出显著努力来改进现有疗法，并开拓针对心脏自主神经靶点的其他干预措施。这些干预措施针对神经心脏轴上多个不同的解剖靶点。本综述的目的是概述心律失常治疗中神经调节的基本原理，并回顾正在评估和开发的用于治疗心房颤动和室性心律失常的具体治疗方法。
