Wobith M, Acikgöz A, Grosser K, Weimann A
Klinik für Allgemein‑, Viszeral- und Onkologische Chirurgie, Klinikum St. Georg Leipzig, Delitzscher Str. 141, 04129, Leipzig, Deutschland.
Chirurg. 2019 Nov;90(11):930-935. doi: 10.1007/s00104-019-01028-2.
Gastrointestinal cancer is a frequent diagnosis in older patients. A curative resection, possibly in combination with radiotherapy and/or chemotherapy, is the standard therapy. The advanced age of the patients with an increasing number of comorbidities and often the presence of cognitive impairment represents a high risk for perioperative complications and a longer stay in hospital. The challenge in the clinical routine is to recognize a cognitive impairment in older patients and to prepare these patients for the operative intervention in the best possible way.
This retrospective analysis was carried out to find out whether preoperative cognitive impairment is a prognostic factor for the postoperative outcome.
In patients over the age of 75 years who were prepared for abdominal surgery of gastrointestinal cancer in the preoperative consultation, the mini mental state examination (MMSE) and the clock test were carried out. The results of the tests were retrospectively compared with the complication rate and the duration of hospital stay.
Low MMSE values were significantly associated with the complication rate and the development of a severe complication (Clavien-Dindo grade ≥ 3a). A cut-off value of 24 points in the MMSE was predictive for the development of complications and a longer hospital stay. The age of the patients was not associated with the MMSE.
Cognitive impairment is an important prognostic factor for the development of perioperative complications and the duration of the hospital stay in patients undergoing extensive abdominal surgery for gastrointestinal cancer. Therefore, a preoperative assessment, for example with the MMSE, is recommended in order to identify high-risk patients.
胃肠道癌在老年患者中是一种常见诊断。根治性切除,可能联合放疗和/或化疗,是标准治疗方法。患者年龄较大,合并症数量不断增加,且常存在认知障碍,这对围手术期并发症构成高风险,且住院时间更长。临床常规中的挑战在于识别老年患者的认知障碍,并以最佳方式为这些患者的手术干预做好准备。
进行这项回顾性分析是为了查明术前认知障碍是否是术后结果的预后因素。
在术前会诊中准备进行胃肠道癌腹部手术的75岁以上患者中,进行简易精神状态检查(MMSE)和时钟测试。将测试结果与并发症发生率和住院时间进行回顾性比较。
低MMSE值与并发症发生率及严重并发症(Clavien-Dindo分级≥3a)的发生显著相关。MMSE中24分的临界值可预测并发症的发生和更长的住院时间。患者年龄与MMSE无关。
认知障碍是接受胃肠道癌广泛腹部手术患者围手术期并发症发生和住院时间的重要预后因素。因此,建议进行术前评估,例如使用MMSE,以识别高危患者。