牛磺酸对电击足底应激诱导的大鼠急性应激的抗氧化和抗应激作用。

Antioxidant and Anti-Stress Effects of Taurine Against Electric Foot-Shock-Induced Acute Stress in Rats.

机构信息

College of Pharmacy, Chosun University, Dong-gu, Gwangju, Republic of Korea.

Department of Marine Bio-Food Sciences, Chonnam National University, Yeosu, Republic of Korea.

出版信息

Adv Exp Med Biol. 2019;1155:185-196. doi: 10.1007/978-981-13-8023-5_17.

DOI:10.1007/978-981-13-8023-5_17

PMID:31468397

Abstract

In the present study, we evaluated the antioxidant and anti-stress activities of taurine in electric foot-shock stress model rats. Taurine supplementation markedly increased the hepatic glutathione (GSH) levels, compared to the levels in the stress group. In addition, activities of antioxidant enzymes such as catalase (CAT), glutathione peroxidase (GPx) and glutathione-S-transferase (GST) were improved in the taurine-treated group. Plasma cortisol and dehydroepiandrosterone-sulfate (DHEA-S) levels were significantly reduced in the taurine-supplemented group compared to those in the stress group. In contrast, the levels of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) were markedly increased in the taurine or betaine-treated group compared to those in the stress group. It may be concluded that taurine produces beneficial effects in the form of antioxidant status and biochemical alterations in foot-shock-induced acute stress in rats.

摘要

在本研究中，我们评估了牛磺酸在电击足底应激模型大鼠中的抗氧化和抗应激活性。与应激组相比，牛磺酸补充显著增加了肝脏谷胱甘肽（GSH）水平。此外，牛磺酸处理组的抗氧化酶如过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GPx）和谷胱甘肽-S-转移酶（GST）的活性也得到了改善。与应激组相比，牛磺酸补充组的血浆皮质醇和脱氢表雄酮硫酸酯（DHEA-S）水平显著降低。相比之下，牛磺酸或甜菜碱处理组的 5-羟色胺（5-HT）和 5-羟吲哚乙酸（5-HIAA）水平明显高于应激组。综上所述，牛磺酸通过改善抗氧化状态和生化变化对电击足底应激诱导的急性应激产生有益影响。