Hot Water Extract of Loliolus beka Meat Attenuates HO-Induced Damage in Human Umbilical Vein Endothelial Cells.

Blood vessels become less flexible with senescence; arteries narrow and become less flexible, disturbing blood circulation in aging and other vascular diseases. Mechanistically, vascular senescence plays an important role in the pathogenesis of normal aging and age-related vascular diseases. Vascular senescence also causes vascular dysfunction, resulting in damage to the vessel wall. Vascular aging involves the senescence of endothelial cells. Hydrogen peroxide is widely used to achieve oxidative stress-induced premature senescence. Here, we investigated the protective effects of a hot water extract of Loliolus beka meat (LBM) against HO-exposed HUVECs, a human umbilical vein endothelial cells line. The hot water extract of LBM protected cells against HO-induced cytotoxicity while reducing the expression of senescence markers, including β-galactosidase, p53, and p21. In addition, the hot water extract of LBM protected against HO-induced DNA damage. These findings suggest that the hot water extract of LBM protects HUVECs from HO-induced senescence by preventing cellular damage. LBM serve as a supplement or natural food with benefits against vascular disease.