Freshwater Biosources Utilization Bureau, Bioresources Industrialization Support Division, Nakdonggang National Institute of Biological Resources (NNIBR), Sangju, Republic of Korea.
Department of Food Technology and Nutrition, Chonnam National University, Yeosu, Republic of Korea.
Adv Exp Med Biol. 2019;1155:705-715. doi: 10.1007/978-981-13-8023-5_61.
Blood vessels become less flexible with senescence; arteries narrow and become less flexible, disturbing blood circulation in aging and other vascular diseases. Mechanistically, vascular senescence plays an important role in the pathogenesis of normal aging and age-related vascular diseases. Vascular senescence also causes vascular dysfunction, resulting in damage to the vessel wall. Vascular aging involves the senescence of endothelial cells. Hydrogen peroxide is widely used to achieve oxidative stress-induced premature senescence. Here, we investigated the protective effects of a hot water extract of Loliolus beka meat (LBM) against HO-exposed HUVECs, a human umbilical vein endothelial cells line. The hot water extract of LBM protected cells against HO-induced cytotoxicity while reducing the expression of senescence markers, including β-galactosidase, p53, and p21. In addition, the hot water extract of LBM protected against HO-induced DNA damage. These findings suggest that the hot water extract of LBM protects HUVECs from HO-induced senescence by preventing cellular damage. LBM serve as a supplement or natural food with benefits against vascular disease.
血管随衰老而变得缺乏弹性；动脉变窄且缺乏弹性，这扰乱了衰老和其他血管疾病中的血液循环。从机制上讲，血管衰老在正常衰老和与年龄相关的血管疾病的发病机制中起着重要作用。血管衰老还会导致血管功能障碍，从而损害血管壁。血管老化涉及内皮细胞的衰老。过氧化氢被广泛用于实现氧化应激诱导的过早衰老。在这里，我们研究了毛蚶肉（LBM）热水提取物对 HO 暴露的人脐静脉内皮细胞（HUVEC）的保护作用，HUVEC 是人脐带静脉内皮细胞系。LBM 的热水提取物可保护细胞免受 HO 诱导的细胞毒性，同时降低衰老标志物（包括β-半乳糖苷酶、p53 和 p21）的表达。此外，LBM 的热水提取物可防止 HO 诱导的 DNA 损伤。这些发现表明，LBM 的热水提取物通过防止细胞损伤来保护 HUVEC 免受 HO 诱导的衰老。LBM 可作为补充剂或天然食品，具有预防血管疾病的功效。
