Division of Public Health, Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
University of Utah School of Medicine, Salt Lake City, UT, USA.
Paediatr Perinat Epidemiol. 2019 Nov;33(6):397-404. doi: 10.1111/ppe.12578. Epub 2019 Aug 29.
Bisphenol A (BPA) is a non-persistent endocrine-disrupting chemical with nearly ubiquitous, involuntary exposure. Previous studies have shown that BPA causes reproductive dysfunction in animal models, but there are limited data regarding the effects of BPA exposure on time to pregnancy (TTP) in humans.
To evaluate whether peri-conceptional BPA exposure of women and men is associated with couples' TTP.
A total of 164 heterosexual couples (164 women; 163 men) who have available BPA information as well as time to pregnancy from the Home Observation of Peri-conceptional Exposures (HOPE) Study were included and were followed up to 12 months. Women collected first-morning urine samples starting at the beginning of the fertile window and continued until the onset of menses or 18 days after the estimated day of ovulation (EDO+18 days). The time to pregnancy (TTP) after the enrolment was self-reported and used for the analysis. Discrete-time Cox proportional hazards models were performed to generate fecundability odds ratio (FOR) between BPA and TTP after adjusting for education and age, accounting for right censoring and prior number of cycles trying to conceive.
Among 164 couples, 125 couples became pregnant during the study. There was no association between TTP and peri-conceptional BPA exposure for both men (FOR 1.02, 95% CI 0.72, 1.47) and women (FOR 1.07, 95% CI 0.75, 1.53) after adjusting for education and age.
No association was found between peri-conceptional BPA exposure and fecundability in this preconception cohort of relatively young, healthy pregnancy planners.
双酚 A（BPA）是一种非持久性内分泌干扰化学物质，具有广泛存在且不可避免的暴露。先前的研究表明，BPA 会导致动物模型的生殖功能障碍，但关于 BPA 暴露对人类妊娠时间（TTP）的影响的数据有限。
评估女性和男性围孕期 BPA 暴露是否与夫妇的 TTP 相关。
共纳入了 164 对有 BPA 信息以及来自家庭观察围孕期暴露（HOPE）研究的 TTP 的时间的异性恋夫妇（164 名女性；163 名男性），并随访了 12 个月。女性从可育窗口开始采集晨尿样本，并持续到月经来潮或估计排卵日（EDO+18 天）后 18 天。在登记后，自我报告妊娠时间（TTP）并用于分析。在调整教育和年龄后，使用离散时间 Cox 比例风险模型生成 BPA 与 TTP 之间的生育能力比值比（FOR），同时考虑右删失和尝试怀孕的先前周期数。
在 164 对夫妇中，有 125 对在研究期间怀孕。在调整教育和年龄后，男性（FOR 1.02，95%CI 0.72，1.47）和女性（FOR 1.07，95%CI 0.75，1.53）围孕期 BPA 暴露与 TTP 之间均无关联。
在这个相对年轻、健康的妊娠计划者的孕前队列中，围孕期 BPA 暴露与生育能力之间没有关联。
