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Can L-glutamine augmented heat shock protein 70 expression prevent exercise-induced exertional heat stroke and sudden cardiac death?L-谷氨酰胺增强热休克蛋白70表达能否预防运动诱发的劳力性中暑和心源性猝死?
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Glutamine induces heat shock protein 70 expression via O-GlcNAc modification and subsequent increased expression and transcriptional activity of heat shock factor-1.谷氨酰胺通过 O-GlcNAc 修饰诱导热休克蛋白 70 的表达,进而增加热休克因子-1 的表达和转录活性。
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本文引用的文献

1
Is Aspirin an Effective Preventive Medicine for Firefighting-Induced Acute Inflammation?阿司匹林是预防消防员急性炎症的有效药物吗?
J Occup Environ Med. 2019 Oct;61(10):e432. doi: 10.1097/JOM.0000000000001680.
2
L-glutamine protects mouse brain from ischemic injury via up-regulating heat shock protein 70.L-谷氨酰胺通过上调热休克蛋白 70 保护小鼠大脑免受缺血性损伤。
CNS Neurosci Ther. 2019 Sep;25(9):1030-1041. doi: 10.1111/cns.13184. Epub 2019 Jun 20.
3
Heat Shock Proteins: Protection and Potential Biomarkers for Ischemic Injury of Cardiomyocytes After Surgery.热休克蛋白:手术后心肌细胞缺血性损伤的保护作用及潜在生物标志物
Braz J Cardiovasc Surg. 2018 May-Jun;33(3):291-302. doi: 10.21470/1678-9741-2017-0169.
4
Fire Simulation and Cardiovascular Health in Firefighters.消防员的火灾模拟与心血管健康
Circulation. 2017 Apr 4;135(14):1284-1295. doi: 10.1161/CIRCULATIONAHA.116.025711.
5
Heat shock protein 70 and AMP-activated protein kinase contribute to 17-DMAG-dependent protection against heat stroke.热休克蛋白70和AMP激活的蛋白激酶有助于17-DMAG介导的中暑防护作用。
J Cell Mol Med. 2016 Oct;20(10):1889-97. doi: 10.1111/jcmm.12881. Epub 2016 May 31.
6
Life-threatening events during endurance sports: is heat stroke more prevalent than arrhythmic death?耐力运动中的危及生命事件:热射病比心律失常性死亡更常见吗?
J Am Coll Cardiol. 2014 Aug 5;64(5):463-9. doi: 10.1016/j.jacc.2014.05.025.
7
A randomized trial of glutamine and antioxidants in critically ill patients.一项关于谷氨酰胺和抗氧化剂在危重症患者中应用的随机试验。
N Engl J Med. 2013 Apr 18;368(16):1489-97. doi: 10.1056/NEJMoa1212722.
8
Heatstroke during endurance exercise: is there evidence for excessive endothermy?耐力运动中的中暑:是否有过热过度产热的证据?
Med Sci Sports Exerc. 2008 Jul;40(7):1193-204. doi: 10.1249/MSS.0b013e31816a7155.
9
Heat shock proteins and the heat shock response during hyperthermia and its modulation by altered physiological conditions.热休克蛋白与热疗过程中的热休克反应及其受生理条件改变的调节。
Prog Brain Res. 2007;162:433-46. doi: 10.1016/S0079-6123(06)62021-9.
10
Oral glutamine enhances heat shock protein expression and improves survival following hyperthermia.口服谷氨酰胺可增强热休克蛋白表达并改善热疗后的存活率。
Shock. 2006 Mar;25(3):295-9. doi: 10.1097/01.shk.0000196548.10634.02.

Can L-glutamine augmented heat shock protein 70 expression prevent exercise-induced exertional heat stroke and sudden cardiac death?

作者信息

Zhang Yang, Bishop Phillip A

机构信息

Faculty for Sport and Physical Education, University of Montenegro, Podgorica, Montenegro.

Department of Kinesiology, University of Alabama, Tuscaloosa, AL, USA.

出版信息

CNS Neurosci Ther. 2020 Jan;26(1):148-150. doi: 10.1111/cns.13217. Epub 2019 Aug 30.

DOI:10.1111/cns.13217
PMID:31469237
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6930829/
Abstract
摘要