Vestische Hospital for Children and Adolescents Datteln, University of Witten/Herdecke, Datteln, Germany.
Pediatr Diabetes. 2019 Dec;20(8):1047-1055. doi: 10.1111/pedi.12915. Epub 2019 Sep 18.
The inflammatory cytokine progranulin has been proposed to play a role in obesity and its associated comorbidities such as insulin resistance.
In a longitudinal study, we analyzed the links between progranulin, parameters of fat mass, insulin resistance, and metabolic syndrome (MetS) in obese children.
We measured the following parameters in 88 obese children at baseline, at the end of a 1-year lifestyle intervention and 1-year later (=2 years after baseline): progranulin, bioactive leptin, body mass index-SD score (BMI-SDS), waist circumference, body fat based on skinfold measurements and bioimpedance analyses, lipids, transaminases, insulin resistance index homeostasis model assessment (HOMA), and blood pressure. As a control, we determined progranulin in 23 normal-weight children.
The progranulin concentrations did not differ significantly (P = .795) between obese and normal-weight children. Progranulin concentrations decreased significantly during and after the lifestyle intervention in children with and without decrease of BMI-SDS. There was no relationship between progranulin concentrations and pubertal stage or gender. Progranulin was not significantly associated with insulin resistance HOMA, parameters of the MetS or transaminases both in cross-sectional and longitudinal multiple linear regression analyses adjusted to multiple confounders. Progranulin was significantly, negatively related to age (b-coefficient -1.24 ± .97, P = .012, r = .07).
Our data do not support the hypothesis that progranulin is an important link between obesity, insulin resistance, and MetS in childhood.
炎症细胞因子颗粒蛋白前体(progranulin)被认为在肥胖及其相关合并症（如胰岛素抵抗）中发挥作用。
在一项纵向研究中，我们分析了颗粒蛋白前体与肥胖儿童体脂参数、胰岛素抵抗和代谢综合征（MetS）之间的关系。
我们在基线时、1 年生活方式干预结束时和 1 年后（=基线后 2 年）测量了 88 名肥胖儿童的以下参数：颗粒蛋白前体、生物活性瘦素、体重指数标准差评分（BMI-SDS）、腰围、皮褶和生物阻抗分析测量的体脂肪、血脂、转氨酶、胰岛素抵抗指数稳态模型评估（HOMA）和血压。作为对照，我们在 23 名正常体重儿童中测定了颗粒蛋白前体。
肥胖儿童和正常体重儿童的颗粒蛋白前体浓度无显著差异（P=0.795）。在有或无 BMI-SDS 下降的儿童中，生活方式干预期间和之后，颗粒蛋白前体浓度均显著下降。颗粒蛋白前体浓度与青春期阶段或性别无显著相关性。在横断面和纵向多元线性回归分析中，调整了多种混杂因素后，颗粒蛋白前体浓度与胰岛素抵抗 HOMA、MetS 参数或转氨酶均无显著相关性。颗粒蛋白前体与年龄呈显著负相关（b 系数-1.24±0.97，P=0.012，r=0.07）。
我们的数据不支持颗粒蛋白前体是儿童肥胖、胰岛素抵抗和 MetS 之间重要联系的假说。
