生物活性瘦素与肥胖儿童生活方式干预研究中常规测量的瘦素相比，与脂肪量和分布的参数相关性更强。
Bioactive leptin is stronger related to parameters of fat mass and distribution than conventionally measured leptin: Findings from a longitudinal study in obese children participating in a lifestyle intervention.
机构信息
Vestische Hospital for Children and Adolescents Datteln, University of Witten/Herdecke, Germany.
Vestische Hospital for Children and Adolescents Datteln, University of Witten/Herdecke, Germany.
出版信息
Clin Chim Acta. 2018 May;480:225-229. doi: 10.1016/j.cca.2018.02.020. Epub 2018 Feb 21.
OBJECTIVE
This study analyzed the relationships between bioactive leptin, conventionally measured leptin, and parameters of fat mass and distribution in obese children before and after weight reduction.
METHODS
We determined bioactive leptin (bioLep), conventional measured leptin (conLep), weight, height, body fat based on skinfold measurements and bioimpedance analyses, waist circumference (wc), and pubertal stage in 88 obese children participating in a lifestyle intervention at baseline and one year later.
RESULTS
We identified no child with homozygous or heterozygous status for bioinactive leptin mutations. The baseline associations between bioLep and BMI (r = 0.53), BMI-SDS (r = 0.48), body fat (bioimpedance: r = 0.61, skinfold thickness: r = 0.49), wc (r = 0.42), and waist to height ratio (whr) (r = 0.39) were stronger than the associations between conLep and BMI (r = 0.50), BMI-SDS (r = 0.44), body fat (bioimpedance: r = 0.57, skinfold thickness: r = 0.41), wc (r = 0.41), and whr (r = 0.37). The changes of bioLep were stronger related to changes of BMI-SDS (r = 0.54), body fat (bioimpedance r = 0.59, skinfold thickness: r = 0.37), wc (r = 0.22), and whr (r = 0.21) than the associations between changes of conLep and changes of BMI-SDS (r = 0.48), body fat (bioimpedance: r = 0.56, skinfold thickness: r = 0.43), wc (r = 0.20), and whr (r = 0.20). The same findings were observed in multiple linear regression analyses adjusted to multiple confounders. In contrast to changes of conLep (r = 0.22), the changes of bioLep during intervention were not related to weight regain after the end of intervention. BioLep concentrations did not differ between prepubertal girls and boys, but were higher in pubertal girls compared to pubertal boys (p = 0.031).
CONCLUSIONS
Bioactive leptin was stronger related to fat mass and distribution compared to conventionally measured leptin.
目的
本研究分析了肥胖儿童减重前后生物活性瘦素（bioLep）、常规测量瘦素（conLep）与体脂量和分布参数之间的关系。
方法
我们在基线和一年后，对 88 名参加生活方式干预的肥胖儿童进行了生物活性瘦素（bioLep）、常规测量瘦素（conLep）、体重、身高、基于皮褶厚度和生物阻抗分析的体脂、腰围（wc）和青春期分期的测定。
结果
我们没有发现生物活性瘦素基因突变的纯合子或杂合子。基线时，bioLep 与 BMI（r=0.53）、BMI-SDS（r=0.48）、体脂（生物阻抗：r=0.61，皮褶厚度：r=0.49）、wc（r=0.42）和腰高比（whr）（r=0.39）的相关性强于 conLep 与 BMI（r=0.50）、BMI-SDS（r=0.44）、体脂（生物阻抗：r=0.57，皮褶厚度：r=0.41）、wc（r=0.41）和 whr（r=0.37）的相关性。bioLep 的变化与 BMI-SDS（r=0.54）、体脂（生物阻抗 r=0.59，皮褶厚度：r=0.37）、wc（r=0.22）和 whr（r=0.21）的变化相关性强于 conLep 的变化与 BMI-SDS（r=0.48）、体脂（生物阻抗：r=0.56，皮褶厚度：r=0.43）、wc（r=0.20）和 whr（r=0.20）的变化相关性。在调整了多种混杂因素的多元线性回归分析中也观察到了相同的结果。与 conLep 的变化（r=0.22）不同，干预期间 bioLep 的变化与干预结束后体重的再次增加无关。青春期前女孩和男孩的 bioLep 浓度没有差异，但青春期女孩的 bioLep 浓度高于青春期男孩（p=0.031）。
结论
与常规测量的瘦素相比，生物活性瘦素与体脂量和分布的相关性更强。
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