Adeyanju Oluwaseun A, Olatunji Lawrence A
Department of Physiology, College of Health Sciences, University of Ilorin, Ilorin 240003, Nigeria.
Cardiometabolic Research Unit, Department of Physiology, Afe Babalola University, Ado-Ekiti, Nigeria.
J Basic Clin Physiol Pharmacol. 2019 Aug 30;30(5):jbcpp-2018-0184. doi: 10.1515/jbcpp-2018-0184.
Background Combined oral contraceptive (COC) use has been associated with an increased risk of insulin resistance (IR) and other adverse cardiovascular events, despite efforts to reduce the dosage and/or progestin type. COC containing drospirenone (DRSP) is an analog of spironolactone, hence its antimineralocorticoid and antiandrogenic characteristics have been deemed beneficial, although the benefits and/or negative outcome of its usage have not been fully elucidated. We therefore hypothesized that COC with DRSP component will not affect glucose regulation and circulating corticosterone. Method Ten-week-old female Wistar rats were divided into three groups: control (CON), ethinylestradiol/drospirenone COC (EE/DRSP)-treated, and ethinylestradiol/levonorgestrel COC (EE/LN)-treated rats. The treatment lasted for 8 weeks. Results Results showed that with the exception of lipid profiles, EE/LN but not EE/DRSP COC treatment affected body weight, glucose tolerance, plasma insulin, corticosterone, (IR), and pancreatic β-cell dysfunction. Conclusion Taken together, the findings showed that the beneficial effect of EE/DRSP could possibly be through the DRSP component. The result also implies that COCs containing DRSP may be a better and safer means of contraception than those with LN with less cardiovascular risks.
背景 尽管一直在努力降低剂量和/或改变孕激素类型，但复方口服避孕药（COC）的使用仍与胰岛素抵抗（IR）风险增加及其他不良心血管事件相关。含屈螺酮（DRSP）的COC是螺内酯的类似物，因此其抗盐皮质激素和抗雄激素特性被认为有益，尽管其使用的益处和/或负面结果尚未完全阐明。因此，我们假设含DRSP成分的COC不会影响葡萄糖调节和循环皮质酮水平。方法 将10周龄雌性Wistar大鼠分为三组：对照组（CON）、接受乙炔雌二醇/屈螺酮COC（EE/DRSP）治疗组和接受乙炔雌二醇/左炔诺孕酮COC（EE/LN）治疗组。治疗持续8周。结果 结果显示，除血脂谱外，EE/LN而非EE/DRSP COC治疗会影响体重、糖耐量、血浆胰岛素、皮质酮、胰岛素抵抗（IR）和胰腺β细胞功能障碍。结论 综上所述，研究结果表明EE/DRSP的有益作用可能是通过DRSP成分实现的。该结果还意味着，含DRSP的COC可能是一种比含LN的COC更好、更安全的避孕方式，心血管风险更低。
