BONENAVI 1版与BONENAVI 2版对原发性乳腺癌骨转移诊断精度的比较。
Comparison of diagnostic precision for bone metastasis of primary breast cancer between BONENAVI version 1 and BONENAVI version 2.
作者信息
Okada Yukinori, Matsushita Shoichiro, Nakajima Yasuo, Yamaguchi Keiichiro, Okuda Itsuko, Kojima Yasuyuki, Tsugawa Koichiro
机构信息
Department of Radiology, St. Marianna University School of Medicine, Kawasaki.
Division of Geriatric Behavioral Neurology CYRIC, Tohoku University, Sendai.
出版信息
Nucl Med Commun. 2019 Nov;40(11):1148-1153. doi: 10.1097/MNM.0000000000001081.
OBJECTIVE
The aim of this study was to compare the diagnostic precision of bone scintigraphy with BONENAVI version 1 and BONENAVI version 2 in bone metastasis of primary breast cancer.
METHODS
The subjects were 56 consecutive patients (all women, mean age 59 ± 12.7 years) who underwent bone scintigraphy with Tc-MDP and were diagnosed with bone metastasis of primary breast cancer from January 2012 to November 2014. Bone scintigraphy was performed with BONENAVI version 1 and BONENAVI version 2 to calculate artificial neural network (ANN), bone scan index (BSI), and hot-spot values, with ANN ≥ 0.5 considered to reflect bone metastasis for the calculation of sensitivity. Mean ANN, BSI, hot-spot values, and sensitivity were compared between BONENAVI version 1 and BONENAVI version 2, with P < 0.05 considered a significant difference.
RESULTS
With BONENAVI version 1, mean ANN was 0.73 ± 0.29, BSI was 1.47 ± 1.85, the hot-spot value was 12.4 ± 12.5, and sensitivity was 76.8% (43/56). With BONENAVI version 2, the mean ANN was 0.86 ± 0.19, BSI was 1.53 ± 2.09, hot-spot value was 12.9 ± 15.6, and sensitivity was 94.6% (53/56). BONENAVI version 2 yielded significantly better ANN and sensitivity than BONENAVI version 1 (both P < 0.01).
CONCLUSION
BONENAVI version 2 has improved sensitivity for detecting bone metastasis of primary breast cancer compared to BONENAVI version 1.
目的
本研究旨在比较BONENAVI 1版和BONENAVI 2版骨闪烁显像在原发性乳腺癌骨转移诊断中的准确性。
方法
选取2012年1月至2014年11月期间连续56例接受锝-亚甲基二膦酸盐（Tc-MDP）骨闪烁显像并被诊断为原发性乳腺癌骨转移的患者（均为女性，平均年龄59±12.7岁）。采用BONENAVI 1版和BONENAVI 2版进行骨闪烁显像，计算人工神经网络（ANN）、骨扫描指数（BSI）和热点值，以ANN≥0.5作为反映骨转移的指标计算敏感度。比较BONENAVI 1版和BONENAVI 2版的平均ANN、BSI、热点值及敏感度，P<0.05为差异有统计学意义。
结果
BONENAVI 1版时，平均ANN为0.73±0.29，BSI为1.47±1.85，热点值为12.4±12.5，敏感度为76.8%（43/56）。BONENAVI 2版时，平均ANN为0.86±0.19，BSI为1.53±2.09，热点值为12.9±15.6，敏感度为94.6%（53/56）。BONENAVI 2版的ANN和敏感度均显著优于BONENAVI 1版（均P<0.01）。
结论
与BONENAVI 1版相比，BONENAVI 2版在检测原发性乳腺癌骨转移方面具有更高的敏感度。
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