Gervasi G B, Bartoli C, Carpita G, Baldacci M
Baldacci Research Laboratories, Pisa, Italy.
Arzneimittelforschung. 1988 Sep;38(9):1268-70.
A peptide fraction of low molecular weight prepared from bovine Factor VIII by enzymatic hydrolysis (Vueffe) reduces bleeding time in laboratory animals. In this study the haemostatic action in mice, rats and rabbits was investigated using different experimental conditions. This action was observed in animals with either normal or experimentally prolonged bleeding time, thus suggesting better efficacy in pathological situations. The evidence obtained following different routes of administration confirmed the activity of the compound. The efficacy was present at very low doses in all animal species without interfering either with platelets or with blood coagulation.
通过酶解（Vueffe）从牛因子VIII制备的低分子量肽级分可缩短实验动物的出血时间。在本研究中，使用不同的实验条件研究了其在小鼠、大鼠和兔子中的止血作用。在出血时间正常或经实验延长的动物中均观察到了这种作用，这表明在病理情况下该肽级分具有更好的疗效。通过不同给药途径获得的证据证实了该化合物的活性。在所有动物物种中，该肽级分在非常低的剂量下就具有疗效，且不影响血小板或血液凝固。
