Ammannati P, Siravo D, Conte B
Clin Ter. 1989 Feb 28;128(4):271-90.
We report pharmacological, experimental and clinical data of the new drug which decreases bleeding time but is devoid of procoagulant and platelet aggregating properties. The drug, derived from bovine factor VIII by enzymatic hydrolysis, did not show toxicological and immunological effects either in animals or in patients. In addition we report the review of the clinical studies in different pathological situations i.e. ophthalmology, odontostomatology, gynecology etc.
我们报告了一种新药的药理学、实验和临床数据，该药物可缩短出血时间，但不具有促凝血和血小板聚集特性。这种药物是通过酶水解从牛因子VIII衍生而来，在动物和患者中均未显示出毒理学和免疫学效应。此外，我们还报告了在不同病理情况下（即眼科、口腔颌面外科学、妇科等）的临床研究综述。
