Department of Life and Health Sciences, University of Nicosia , Nicosia , Cyprus.
The Cyprus Institute of Neurology and Genetics , Nicosia , Cyprus.
Postgrad Med. 2019 Sep;131(7):453-460. doi: 10.1080/00325481.2019.1662271. Epub 2019 Oct 1.
: Recent evidence suggests an association between functional capacity and cognitive function, at least in older adults. The aim of this cross-sectional study was to examine the association between cognitive function, functional capacity, isokinetic leg strength, health-related quality of life (HRQOL), sleep quality, body fat, handgrip strength, and fatigue among a sample of MS patients. : Fifty-one relapsing-remitting MS patients (age: 38.4 ± 7.1 yrs; 30 females) were recruited and agreed to participate in this study. Cognitive function was assessed by the Paced Auditory Serial Addition Test (PASAT). Functional capacity was examined using various functional tests commonly used in MS patients. Maximal voluntary unilateral leg strength was assessed using isokinetic dynamometer. Isometric handgrip strength was assessed by a dynamometer. Total body and visceral fat levels were assessed via bioelectrical impedance analyzers. Finally, the patients' HRQOL, sleep quality, and fatigue levels were evaluated using specific questionnaires. : A significant association was found between the PASAT score and the performance score in various functional capacity tests (p < 0.050). On the other hand, a weak but statistically significant association was found between the PASAT score and isokinetic strength of knee extensors (r = 0.319, p = 0.022) and knee flexors (r = 0.354 p = 0.011). Poor sleep quality was associated with lower performance in all the functional capacity tests examined (p < 0.05) whilst was negatively associated with the PASAT score (r = -0.334, p = 0.017). The multivariate regression analysis revealed that the performance on the TUG test was a significant predictor of cognitive function. : Based on the results of this study, functional capacity was found to be associated with both impaired cognitive performance and low HRQOL in MS patients. In addition, an association between sleep quality and cognitive performance was revealed, confirming existing literature. Functional capacity as assessed by the TUG test emerged as the best predictor of cognitive function.
: 最近的证据表明，功能能力与认知功能之间存在关联，至少在老年人中是这样。本横断面研究的目的是检查认知功能、功能能力、等速腿部力量、健康相关生活质量（HRQOL）、睡眠质量、体脂肪、手握力和疲劳之间的关联，研究对象为一组 MS 患者。 : 共招募了 51 名复发缓解型 MS 患者（年龄：38.4±7.1 岁；30 名女性），他们同意参与本研究。认知功能通过听觉连续加法测试（PASAT）进行评估。使用常用于 MS 患者的各种功能测试来检查功能能力。使用等速测力计评估最大自愿单侧腿部力量。使用测力计评估等长手握力。通过生物电阻抗分析仪评估全身和内脏脂肪水平。最后，通过特定问卷评估患者的 HRQOL、睡眠质量和疲劳水平。 : 在 PASAT 分数和各种功能能力测试的表现分数之间发现了显著的相关性（p＜0.050）。另一方面，在 PASAT 分数和膝关节伸肌（r=0.319，p=0.022）和膝关节屈肌（r=0.354，p=0.011）的等速力量之间发现了微弱但具有统计学意义的相关性。较差的睡眠质量与所有检查的功能能力测试的表现较差相关（p＜0.05），并且与 PASAT 分数呈负相关（r=-0.334，p=0.017）。多元回归分析表明，TUG 测试的表现是认知功能的重要预测指标。 : 根据本研究的结果，在 MS 患者中，功能能力与认知功能受损和 HRQOL 降低均有关联。此外，还揭示了睡眠质量与认知功能之间的关联，证实了现有文献。TUG 测试评估的功能能力是认知功能的最佳预测指标。
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