Giannaki Christoforos D, Aristotelous Panagiotis, Stefanakis Manos, Hadjigeorgiou Georgios M, Manconi Mauro, Leonidou Eleni, Sakkas Giorgos K, Pantzaris Marios
a Department of Life and Health Sciences , University of Nicosia , Nicosia , Cyprus.
b The Cyprus Institute of Neurology and Genetics , Nicosia , Cyprus.
Neurol Res. 2018 Jul;40(7):586-592. doi: 10.1080/01616412.2018.1454719. Epub 2018 Mar 26.
Objectives Restless legs syndrome (RLS) symptoms are common in Multiple Sclerosis (MS) patients. The aim of the current study was to examine for the first time whether RLS could affect the functional capacity and various contributing parameters related to quality of life and fatigue in MS patients. Methods According to their RLS status, 50 relapsing-remitting MS patients were divided into the RLS (n = 10) and non-RLS groups (n = 40). Specific questionnaires were used in order to assess the health-related quality of life (HRQoL), fatigue levels, sleep quality, daily sleepiness, and depression symptoms of the patients. Functional capacity was examined using a battery of functional tests. Total body and visceral fat levels were assessed via bioelectrical impedance analyzers. Results Sleep quality, depression, fatigue, and HRQoL levels were found to be significantly worse in the patients with RLS compared to their free-RLS counterparts (P < 0.05). In addition, patients with RLS were found to exhibit further impairments in their performance in various functional tests related mainly with strength levels of lower extremities (P < 0.05). Finally, the patients with RLS were found to have significantly higher both total and trunk fat levels compared to patients without RLS (P < 0.05). A strong correlation was observed between the severity of RLS symptoms, sleep quality, fatigue, and QoL levels. Discussion It seems that RLS contributes even further to impairments on sleep quality, fatigue, functional capacity, and therefore HRQoL levels in relapsing-remitting MS patients, whilst for the first time a link between high fat levels has been revealed.
目的 不安腿综合征（RLS）症状在多发性硬化症（MS）患者中很常见。本研究的目的是首次检验RLS是否会影响MS患者的功能能力以及与生活质量和疲劳相关的各种影响因素。方法 根据RLS状态，将50例复发缓解型MS患者分为RLS组（n = 10）和非RLS组（n = 40）。使用特定问卷评估患者的健康相关生活质量（HRQoL）、疲劳水平、睡眠质量、日间嗜睡和抑郁症状。通过一系列功能测试检查功能能力。使用生物电阻抗分析仪评估全身和内脏脂肪水平。结果 与无RLS的患者相比，RLS患者的睡眠质量、抑郁、疲劳和HRQoL水平明显更差（P < 0.05）。此外，发现RLS患者在主要与下肢力量水平相关的各种功能测试中的表现进一步受损（P < 0.05）。最后，与无RLS的患者相比，RLS患者的总脂肪和躯干脂肪水平明显更高（P < 0.05）。观察到RLS症状的严重程度、睡眠质量、疲劳和生活质量水平之间存在强烈相关性。讨论 似乎RLS会进一步导致复发缓解型MS患者的睡眠质量、疲劳、功能能力受损，进而影响HRQoL水平，同时首次揭示了高脂肪水平之间的联系。
