Inonu University, Faculty of Health Sciences, Physiotherapy and Rehabilitation Department, Malatya, Türkiye.
Inonu University, Faculty of Medicine, Neurology Department, Malatya, Türkiye.
Arq Neuropsiquiatr. 2024 Sep;82(9):1-9. doi: 10.1055/s-0044-1788273. Epub 2024 Aug 26.
Cognitive dysfunction is frequently seen in multiple sclerosis (MS). However, there are conflicting findings regarding the factors it is associated with.
To investigate the relationship between aerobic capacity, strength, disability, depression, fatigue, and cognitive reserve and function.
The mobile applications Trail Making Test (TMT A-B), Digit Span Test (DST), Visuospatial Memory Test (VSMT), and Tap Fast were used in the cognitive function evaluation. Functional performance was assessed with the 6-minute walk test (6MWT), 5-Time Sit-to-Sand (5STS) test, and grip strength. Cognitive Reserve Index (CRI), Beck Depression Inventory, Fatigue Severity Scale (FSS), and Nottingham Health Profile were also used.
A significant difference was found between the MS and control groups only in the 6MWT, STS-5, grip strength, TMT, VSMT, and Tap Fast. Good correlation was found between the TMT-A and 6MWT and physical mobility. A fair correlation was shown between grip strength, energy, and pain status. A good correlation was found between TMT-B and 6MWT, and a fair relationship with disability, cognitive reserve, and pain. Good correlation was observed between the DST and 6MWT, left grip strength, pain, and energy status; fair correlations were found between right grip strength, cognitive reserve, and physical mobility. Good correlation was found between the VSMT and energy. A fair relationship between disability, cognitive reserve, and pain was demonstrated. Good correlation was observed between the Tap Fast score and disability, 5STS, FSS, energy, and physical mobility. A fair relationship was found between pain and social isolation.
It has been shown that cognitive performance in MS is related to disability, functional performance, cognitive reserve, fatigue, and general health.
NCT06084182.
认知功能障碍在多发性硬化症（MS）中很常见。然而，关于其相关因素的研究结果存在矛盾。
研究有氧能力、力量、残疾、抑郁、疲劳和认知储备与认知功能之间的关系。
使用移动应用程序的连线测试 A-B（TMT A-B）、数字跨度测试（DST）、视觉空间记忆测试（VSMT）和快速敲击测试进行认知功能评估。使用 6 分钟步行测试（6MWT）、5 次坐-站（5STS）测试和握力来评估功能表现。还使用了认知储备指数（CRI）、贝克抑郁量表、疲劳严重程度量表（FSS）和诺丁汉健康概况量表。
MS 组和对照组之间仅在 6MWT、STS-5、握力、TMT、VSMT 和快速敲击测试方面存在显著差异。TMT-A 与 6MWT 和身体移动性之间存在良好的相关性。握力、能量和疼痛状态之间显示出适度的相关性。TMT-B 与 6MWT 之间存在良好的相关性，与残疾、认知储备和疼痛之间存在适度的关系。DST 与 6MWT、左握力、疼痛和能量状态之间存在良好的相关性，与右握力、认知储备和身体移动性之间存在适度的相关性。VSMT 与能量之间存在良好的相关性。残疾、认知储备和疼痛之间存在适度的关系。Tap Fast 评分与残疾、5STS、FSS、能量和身体移动性之间存在良好的相关性。疼痛与社会隔离之间存在适度的关系。
研究表明，MS 患者的认知表现与残疾、功能表现、认知储备、疲劳和整体健康有关。
NCT06084182。
