Maresz Z
Arch Immunol Ther Exp (Warsz). 1975;23(3):361-5.
During electrophoresis in polyacrylamide gel at pH 9-5, it was noticed that sialic acid-poor thyroglobulin contains fewer low molecular weight fragments than sialic acid-rich thyroglobulin. Splitting off of sialic acid diminishes thenumber of phenolic groups of tyrosine, MIT, DIT and T4, which dissociate below pH 12-5. This phenomenon was interpreted as a result of lowered hydrophilia of these regions of the thyroglobulin molecule which contains tyrosine and its iodinated derivatives.
在pH 9 - 5的聚丙烯酰胺凝胶电泳过程中，人们注意到，缺乏唾液酸的甲状腺球蛋白所含的低分子量片段比富含唾液酸的甲状腺球蛋白少。唾液酸的去除减少了酪氨酸、一碘甲腺原氨酸、二碘甲腺原氨酸和甲状腺素酚基团的数量，这些基团在pH 12 - 5以下会解离。这种现象被解释为甲状腺球蛋白分子中含有酪氨酸及其碘化衍生物的这些区域亲水性降低的结果。
