白细胞介素-12/23 中和对小鼠和人类的斑秃无效。
IL-12/IL-23 neutralization is ineffective for alopecia areata in mice and humans.
机构信息
Department of Dermatology, Carver College of Medicine, University of Iowa, Iowa City, Iowa.
Yale School of Medicine, New Haven, Conn.
出版信息
J Allergy Clin Immunol. 2019 Dec;144(6):1731-1734.e1. doi: 10.1016/j.jaci.2019.08.014. Epub 2019 Aug 27.
Abstract
Ustekinumab is currently being explored for the treatment of alopecia areata. Here, our work in a murine model and in human patients indicates that neutralization of the IL-12 and IL-23 pathways does not ameliorate disease.
摘要
乌司奴单抗目前正在探索用于治疗斑秃。在这里，我们在小鼠模型和人类患者中的工作表明，中和 IL-12 和 IL-23 通路并不能改善疾病。
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