Sakhi Hamza, Moktefi Anissa, Bouachi Khedidja, Audard Vincent, Hénique Carole, Remy Philippe, Ollero Mario, El Karoui Khalil
AP-HP (Assistance Publique des Hôpitaux de Paris), Department of Nephrology and Renal Transplantation, Groupe Hospitalier Henri-Mondor, 94010 Créteil, France.
UPEC (Université Paris Est Créteil), UMR-S955, 94010 Créteil, France.
J Clin Med. 2019 Aug 29;8(9):1340. doi: 10.3390/jcm8091340.
Systemic lupus erythematosus (SLE) is characterized by a broad spectrum of renal lesions. In lupus glomerulonephritis, histological classifications are based on immune-complex (IC) deposits and hypercellularity lesions (mesangial and/or endocapillary) in the glomeruli. However, there is compelling evidence to suggest that glomerular epithelial cells, and podocytes in particular, are also involved in glomerular injury in patients with SLE. Podocytes now appear to be not only subject to collateral damage due to glomerular capillary lesions secondary to IC and inflammatory processes, but they are also a potential direct target in lupus nephritis. Improvements in our understanding of podocyte injury could improve the classification of lupus glomerulonephritis. Indeed, podocyte injury may be prominent in two major presentations: lupus podocytopathy and glomerular crescent formation, in which glomerular parietal epithelial cells play also a key role. We review here the contribution of podocyte impairment to different presentations of lupus nephritis, focusing on the podocyte signaling pathways involved in these lesions.
系统性红斑狼疮（SLE）的特征是存在广泛的肾脏病变。在狼疮性肾小球肾炎中，组织学分类基于肾小球中的免疫复合物（IC）沉积和细胞增多性病变（系膜和/或毛细血管内）。然而，有令人信服的证据表明，肾小球上皮细胞，尤其是足细胞，也参与了SLE患者的肾小球损伤。现在看来，足细胞不仅会因IC和炎症过程继发的肾小球毛细血管病变而受到间接损伤，而且它们也是狼疮性肾炎潜在的直接靶点。我们对足细胞损伤认识的提高可能会改进狼疮性肾小球肾炎的分类。事实上，足细胞损伤可能在两种主要表现中较为突出：狼疮性足细胞病和肾小球新月体形成，其中肾小球壁层上皮细胞也起关键作用。我们在此综述足细胞损伤对狼疮性肾炎不同表现的作用，重点关注这些病变中涉及的足细胞信号通路。
