Guo Zhiying, Guo Qianyu, Li Xiaochen, Gao Xinnan, Zhang Liyun, Xu Ke
Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China.
Front Pharmacol. 2024 Jan 19;15:1324540. doi: 10.3389/fphar.2024.1324540. eCollection 2024.
The most prevalent and devastating form of organ damage in systemic lupus erythematosus (SLE) is lupus nephritis (LN). LN is characterized by glomerular injury, inflammation, cell proliferation, and necrosis, leading to podocyte injury and tubular epithelial cell damage. Assays for urine biomarkers have demonstrated significant promise in the early detection of LN, evaluation of disease activity, and tracking of reaction to therapy. This is because they are non-invasive, allow for frequent monitoring and easy self-collection, transport and storage. Podocyte injury is believed to be a essential factor in LN. The extent and type of podocyte injury could be connected to the severity of proteinuria, making podocyte-derived cellular debris and injury-related urinary proteins potential markers for the diagnosis and monitoring of LN. This article focuses on studies examining urinary biomarkers associated with podocyte injury in LN, offering fresh perspectives on the application of biomarkers in the early detection and management of LN.
系统性红斑狼疮（SLE）中最常见且最具破坏性的器官损伤形式是狼疮性肾炎（LN）。LN的特征是肾小球损伤、炎症、细胞增殖和坏死，导致足细胞损伤和肾小管上皮细胞损害。尿液生物标志物检测在LN的早期检测、疾病活动评估及治疗反应跟踪方面已显示出巨大潜力。这是因为它们是非侵入性的，便于频繁监测且易于自行采集、运输和储存。足细胞损伤被认为是LN的一个关键因素。足细胞损伤的程度和类型可能与蛋白尿的严重程度相关，使得源自足细胞的细胞碎片和与损伤相关的尿液蛋白成为LN诊断和监测的潜在标志物。本文重点关注研究与LN中足细胞损伤相关的尿液生物标志物，为生物标志物在LN的早期检测和管理中的应用提供新视角。
